ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.
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Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Triggers of Guillain-Barré Syndrome:International journal of molecular sciences · 2022Pooled it
- Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022Pooled it
- Guillain Barré syndrome associated with COVID-19- lessons learned about its pathogenesis during the first year of the pandemic, a systematic review.Autoimmunity reviews · 2021Pooled it
- Cerebrospinal fluid in COVID-19: A systematic review of the literature.Journal of the neurological sciences · 2021Pooled it
- Autoantigens of Small Nerve Fibers and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?Current microbiology · 2024Article
- Incidence and management of the main serious adverse events reported after COVID-19 vaccination.Pharmacology research & perspectives · 2024Review
- [Miller-Fisher/Guillain-Barré overlap syndrome following COVID-19 vaccination].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Central nervous system immune-related disorders after SARS-CoV-2 vaccination: a multicenter study.Frontiers in immunology · 2024Article
- Neurological complications after COVID-19: A narrative review.eNeurologicalSci · 2023Review
- Sudden Death Is More Likely to Result From SARS-COV-2 Infection Than Multiple Sclerosis.Journal of Korean medical science · 2023Article
- Correlation of covid-19 and Guillain-Barré syndrome: A Mechanistic Perspective.Obesity medicine · 2023Review
- Letter to the Editor Regarding 'A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID19 infection during pregnancy: cause or coincidence?'Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- COVID-19 as a trigger of Guillain-Barré syndrome: A review of the molecular mechanism.Immunity, inflammation and disease · 2023Review
- Guillain-Barre syndrome with pleocytosis requires workup for cerebral disease.Clinical case reports · 2023Article
- Two Case Reports of Newly Diagnosed Crohn's Disease after COVID-19 in Pediatric Patients.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Article
- SARS-CoV-2 associated acute, motor and sensory, axonal neuropathy requires comprehensive diagnostic work-up.Neurosciences (Riyadh, Saudi Arabia) · 2023Article
- SARS-CoV-2-related polyradiculitis must be preceded by PCR-confirmed COVID-19.Clinical case reports · 2023Article
- Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023Article
- SARS-CoV-2 Vaccination Related, Pediatric Guillain-Barre Syndrome Requires the Same Management as in Adults.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Rule Out Alternative Causes Before Attributing Acute, Haemorrhagic, Leukoencephalitis (AHLE) to COVID-19.The Neurohospitalist · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the clinical and immunological features in a case of SARS-CoV-2-induced Guillain-Barré syndrome (Si-GBS), suggesting that (1) Si-GBS can develop even after paucisymptomatic COVID-19 infection; (2) a distinctive cytokine repertoire is associated with this autoimmune complication, with increased CSF concentration of IL-8, and moderately increased serum levels of IL-6, IL-8, and TNF-α; (3) a particular genetic predisposition can be relevant, since the patient carried several HLA alleles known to be associated with GBS, including distinctive class I (HLA-A33) and class II alleles (DRB1*03:01 and DQB1*05:01). To the best of our knowledge, this is the first case of GBS in which SARS-CoV-2 antibodies were detected in the CSF, further strengthening the role of the virus as a trigger. In conclusion, our study suggests that SARS-CoV-2 antibodies need to be searched in the serum and CSF in patients with GBS living in endemic areas, even in the absence of a clinically severe COVID-19 infection, and that IL-8 pathway can be relevant in Si-GBS pathogenesis. Further studies are needed to conclude on the relevance of the genetic findings, but it is likely that HLA plays a role in this setting as in other autoimmune neurological syndromes, including those triggered by infections.
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