ArticleClinical neuroradiology2021
Thrombus Histology of Basilar Artery Occlusions : Are There Differences to the Anterior Circulation?
Article in Clinical neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Bridging thrombolysis versus direct thrombectomy in acute ischemic stroke with large vessel occlusion: a network meta-analysis.Journal of neurology · 2025Pooled it
- Electrical impedance spectroscopy signatures of red blood cells and platelets in acute ischemic stroke clots in the Clotbase International Registry: Significance for etiology and first pass effect.Journal of neurointerventional surgery · 2026Article
- Tenecteplase Versus Alteplase for First-Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy.Annals of neurology · 2026Article
- Quantitative histopathological analysis of thrombi retrieved by mechanical thrombectomy and their association with stroke aetiology.Stroke and vascular neurology · 2025Article
- Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- Posterior Circulation Stroke Patients Receive Less Reperfusion Therapy Because of Late Arrival and Relative Contraindications: A Retrospective Study.Journal of clinical medicine · 2023Article
- Endovascular Treatment of Basilar Artery Occlusion: What Can We Learn from the Results?Medicina (Kaunas, Lithuania) · 2022Article
- Histology of Cerebral Clots in Cryptogenic Stroke Varies According to the Presence of a Patent Foramen Ovale.International journal of molecular sciences · 2022Article
- CT Marker in Emergency Imaging of Acute Basilar Artery Occlusion: Thrombosis vs. Embolism.Diagnostics (Basel, Switzerland) · 2022Article
- Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.Biomedical engineering letters · 2022Article
- Ischemic Stroke of Suspected Cardioembolic Origin Despite Anticoagulation: Does Thrombus Analysis Help to Clarify Etiology?Frontiers in neurology · 2022Article
- Clot Composition Analysis as a Diagnostic Tool to Gain Insight into Ischemic Stroke Etiology: A Systematic Review.Journal of stroke · 2021Review
- [Endovascular treatment of acute basilar artery occlusions].Der Nervenarzt · 2021Review
- No Association Between Thrombus Perviousness and Cardioembolic Stroke Etiology in Basilar Artery Occlusion Stroke.Frontiers in neurology · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing for this subgroup. The aim of the study was to investigate thrombus histology for patients with basilar artery occlusions and uncover differences to anterior circulation clots with respect to underlying etiology.
methodsA total of 59 basilar thrombi were collected during intracranial mechanical recanalization and quantitatively analyzed in terms of their relative fractions of the main constituents, e.g. fibrin/platelets (F/P), red (RBC) and white blood cells (WBC). Data were compared to histopathological analyses of 122 thrombi of the anterior circulation with respect to underlying pathogenesis.
resultsThe composition of basilar thrombi differed significantly to thrombi of the anterior circulation with an overall higher RBC amount (median fraction in % (interquartile range):0.48 (0.37-0.69) vs. 0.37 (0.28-0.50), p < 0.001) and lower F/P count (0.45 (0.21-0.58) vs. 0.57 (0.44-0.66), p < 0.001). Basilar thrombi composition did not differ between the different etiological stroke subgroups.
conclusionThe results depict a differing thrombus composition of basilar thrombi in comparison to anterior circulation clots with an overall higher amount of RBC. This may reflect different pathophysiologic processes between anterior and posterior circulation thrombogenesis, e.g. a larger proportion of appositional thrombus growth in the posterior circulation.
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