Evidence map›Paper›PMID 33006314›Full record

ArticleeLife2020

GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation.

Ming Li, Zhongyu Xie, Jinteng Li, Jiajie Lin, Guan Zheng, Wenjie Liu, Su'an Tang, Shuizhong Cen, Guiwen Ye, Zhaofeng Li and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  5. Article
  6. Autophagy: regulating the seesaw of bone-fat balance.Frontiers in cell and developmental biology · 2025
    Review
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  8. Article
  9. Article
  10. Review
  11. Review
  12. [Lnc-TMEM132D-AS1 overexpression reduces sensitivity of non-small cell lung cancer cells to osimertinib].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. The Roles ofGenes · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ming Li *Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Zhongyu Xie *Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jinteng Li *Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jiajie LinDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Guan ZhengDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Wenjie LiuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Su'an TangDepartment of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shuizhong CenDepartment of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Guiwen YeDepartment of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Zhaofeng LiDepartment of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Wenhui YuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Peng WangDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yanfeng WuCenter for Biotherapy,The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Huiyong ShenDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.ORCID https://orcid.org/0000-0001-7104-3049
Sun Yat-sen University · CNZhujiang Hospital · CN

Funding

Fundamental Research Funds for the Central Universities 19ykpy01Guangdong Provincial Key R&D Programme 2019B020236001Ken Realm R&D Program of Guangdong Province 2019B020236001National Natural Science Foundation of China 81672097National Natural Science Foundation of China 81702120National Natural Science Foundation of China 81871750National Natural Science Foundation of China 81971518
6 · The paper itself

Abstract

Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. It is still necessary to explore its detailed mechanisms and identify novel targets for the treatment of osteoporosis. Previously, we found that a lncRNA named

Indexed as

AnimalsBlotting, WesternCell DifferentiationElectrophoresis, Agar GelFemaleHumansIn Situ Hybridization, FluorescenceMaleMiceMice, Inbred C57BLOsteoblastsOsteoporosisRNA HelicasesRNA, Long NoncodingSmad7 ProteinTrans-ActivatorsGAS5 long non-coding RNA, humanRNA HelicasesRNA, Long NoncodingSmad7 ProteinSMAD7 protein, humanTrans-ActivatorsUPF1 protein, humanbone marrowcell biologyGAS5humanmouseosteoblast differentiationosteoporosisstromal cells

Identifiers

PMID33006314
PMCPMC7609060
OpenAlexW3089412380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.