ArticleeLife2020
Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis.International journal of oral science · 2026Article
- A dual role for GLI3 signaling in neural crest development.Development (Cambridge, England) · 2026Article
- Centriolar protein PIBF1 is required for craniofacial and forebrain development.Developmental biology · 2025Article
- GliFHV mice: a tool to investigate GLI processing and localization.Development (Cambridge, England) · 2025Article
- Generation of Hoxa11-3XFLAG and Hoxd11-3XFLAG alleles to investigate Hox11 genome-wide binding.Developmental biology · 2025Article
- A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate.eLife · 2025Article
- Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.PloS one · 2025Article
- The Contribution of Meckel's Cartilage-Derived Type II Collagen-Positive Cells to the Jawbone Development and Repair.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors.bioRxiv : the preprint server for biology · 2024Article
- Endothelin signaling in development.Development (Cambridge, England) · 2023Review
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.PLoS genetics · 2023Article
- Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.Development (Cambridge, England) · 2023Article
- Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer.PLoS genetics · 2022Article
- GLI transcriptional repression is inert prior to Hedgehog pathway activation.Nature communications · 2022Article
- Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling.Development (Cambridge, England) · 2021Article
- Sonic hedgehog signaling in craniofacial development.Differentiation; research in biological diversityReview
- The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning.Differentiation; research in biological diversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Kelsey H ElliottDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Xiaoting ChenCenter for Autoimmune Genomics and Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Joseph SalomoneDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Praneet ChaturvediDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Preston A SchultzDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Sai K BalchandDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Jeffrey D ServetasJackson Laboratory, Bar Harbor, United States.
Aimée ZunigaDevelopmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
Rolf ZellerDevelopmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
Brian GebeleinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.ORCID 0000-0001-9791-9061
Matthew T WeirauchDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Kevin A PetersonJackson Laboratory, Bar Harbor, United States.
Samantha A BrugmannDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.ORCID 0000-0002-6860-6450
Cincinnati Children's Hospital Medical Center · USJackson Laboratory · USUniversity of Basel · CH
Funding
Harnessing the therapeutic potential of neural crest cells by manipulating the primary ciliumR35DE027557 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2017 to 2024
$7.6MMedical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7MMechanisms of Homeodomain Transcriptional SpecificityR01GM079428 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI GEBELEIN, BRIAN · 2008 to 2023
$4.5MTranscriptional control of Hedgehog/Gli target enhancersR01GM124251 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAROLO, SCOTT, PETERSON, KEVIN ANTHONY · 2017 to 2020
$1.4MInvestigating the role of Gli activator in development of the murine mandibular prominenceF31DE027872 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI ELLIOTT, KELSEY · 2018 to 2020
$71kNIDCR NIH HHS F31 DE027872NIDCR NIH HHS R35 DE027557NIGMS NIH HHS R01 GM079428NIGMS NIH HHS R01 GM124251NIGMS NIH HHS T32 GM063483
Abstract
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (
Indexed as
Maxillofacial DevelopmentAnimalsBasic Helix-Loop-Helix ProteinsFemaleMaleMiceModels, AnimalNerve Tissue ProteinsSkullZinc Finger Protein Gli3Basic Helix-Loop-Helix ProteinsGli3 protein, mouseHand2 protein, mouseNerve Tissue ProteinsZinc Finger Protein Gli3cis-regulatory modulesdevelopmental biologyfunctional genomicGli transcription factorsHand2low affinity bindingmandiblemouse
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.