Evidence map›Paper›PMID 33006312›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

Nocturnal hypoxemia measured by polysomnogram is associated with acute chest syndrome in pediatric sickle cell disease.

Anis Rabbani Nourani, A K M Fazlur Rahman, Brandi Pernell, Mary H Maddox, Lee Hilliard, Jeffrey Lebensburger, Ammar Saadoon Alishlash

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Multicenter comparative study of polysomnography outcomes in children with the monogenic disorder sickle cell disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  5. Article
  6. Understanding the impact of nocturnal hypoxemia in pediatric sickle cell disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anis Rabbani NouraniDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
A K M Fazlur RahmanDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
Brandi PernellDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Mary H MaddoxDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Lee HilliardDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Jeffrey LebensburgerDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ammar Saadoon AlishlashDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · US

Funding

DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAMKL2TR003097 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$5.2M
NCATS NIH HHS KL2 TR003097
6 · The paper itself

Abstract

STUDY

objectivesNocturnal hypoxemia is associated with increased risk of sickle cell disease (SCD) complications. The association of nighttime hypoxemia and acute chest syndrome (ACS) in children with SCD has yet to be determined.

methodsThis is a retrospective study of children with SCD who underwent polysomnography at a SCD center. Univariate logistic regression was used to assess the association between nocturnal hypoxemia and ACS admissions. Multivariate logistic regression was performed to verify the effects of different clinical covariates on ACS. Secondary analysis comparing patients with one vs multiple ACS admissions was performed.

resultsOne hundred ten individuals with SCD who completed their polysomnogram (mean age of 9.4 years) were identified. Fifty-nine (54%) had a history of at least one episode of ACS admission (mean age of 4.1 years), including 40 with multiple episodes. The percentage of total sleep time with O₂ saturation < 90% was greater in the ACS group (P < .05). Similarly, mean nocturnal O₂ saturation was lower in the ACS group (P < .0005). Mean nocturnal O₂ saturation of < 97.3% and the percentage of total sleep time with O₂ saturation < 90% higher than 2.7% were associated with ACS. There was no difference in nocturnal hypoxemia between patients with single and multiple ACS admissions.

conclusionsNocturnal hypoxemia later in life is associated with previous ACS admissions in children with SCD. This can increase the yield of interpreting polysomnograms in this vulnerable population. Prospective studies are needed to determine the temporal relations of nocturnal hypoxemia and ACS, which may identify a modifiable risk for ACS.

Indexed as

Acute Chest SyndromeAnemia, Sickle CellChildChild, PreschoolHumansHypoxiaPolysomnographyProspective StudiesRetrospective Studiesacute chest syndromeasthmahypoxianighttimenocturnalpediatricpolysomnographysickle cell diseasesleep study

Identifiers

PMID33006312
PMCPMC7853222
OpenAlexW3091148977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.