Evidence map›Paper›PMID 33006296›Full record

ArticleJournal of the American Heart Association2020

Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy.

Ibolya Csecs, Farhad Pashakhanloo, Amanda Paskavitz, Jihye Jang, Talal Al-Otaibi, Ulf Neisius, Warren J Manning, Reza Nezafat

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Simultaneous free-breathing T1, T2, and T1ρ mapping for myocardial fibrosis detection in non-ischemic cardiomyopathy: A comparative study with conventional techniques.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  4. Article
  5. Article
  6. Gadolinium-Free Cardiac MRI Myocardial Scar Detection by 4D Convolution Factorization.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Spatiotemporal deep learning for scar screening in cardiovascular magnetic resonance: Toward selective use of gadolinium.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ibolya CsecsDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Farhad PashakhanlooDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Amanda PaskavitzDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Jihye JangDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Talal Al-OtaibiDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Ulf NeisiusDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Warren J ManningDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Reza NezafatDepartment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Beth Israel Deaconess Medical Center · US

Funding

Cardiovascular MRI Characterization of the Arrhythmogenic Heart in Nonischemic CardiomyopathyR01HL129185 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2015 to 2024
$6.4M
Imaging Markers of Subclinical Cardiotoxicity in Breast CancerR01HL127015 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2016 to 2020
$3.5M
Myocardial Tissue Characterization with MR Relaxometry in Heart FailureR01HL129157 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2017 to 2020
$3.2M
NHLBI NIH HHS R01 HL127015NHLBI NIH HHS R01 HL129157NHLBI NIH HHS R01 HL129185
6 · The paper itself

Abstract

Background In patients with nonischemic cardiomyopathy, nonischemic fibrosis detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance is related to adverse cardiovascular outcomes. However, its relationship with left ventricular (LV) mechanical deformation parameters remains unclear. We sought to investigate the association between LV mechanics and the presence, location, and extent of fibrosis in patients with nonischemic cardiomyopathy. Methods and Results We retrospectively identified 239 patients with nonischemic cardiomyopathy (67% male; 55±14 years) referred for a clinical cardiovascular magnetic resonance. LGE was present in 109 patients (46%), most commonly (n=52; 22%) in the septum. LV deformation parameters did not differentiate between LGE-positive and LGE-negative groups. Global longitudinal, radial, and circumferential strains, twist and torsion showed no association with extent of fibrosis. Patients with septal fibrosis had a more depressed LV ejection fraction (30±12% versus 35±14%;

Indexed as

Ventricular RemodelingCardiomyopathiesFemaleFibrosisHeartHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumRetrospective StudiesStroke Volumecardiac magnetic resonance imaginglate gadolinium enhancementmyocardial mechanicsnonischemic dilated cardiomyopathystrains

Identifiers

PMID33006296
PMCPMC7792406
OpenAlexW3090676185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.