ArticleIrish journal of medical science2021
The relationship between cognition, depression, fatigue, and disability in patients with multiple sclerosis.
Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors - A Systematic Review and Meta-Analysis.Annals of clinical and translational neurology · 2026Pooled it
- Association between CHI3L1 and CRTH2 genetic variants, clinical phenotype, and neurological disability in multiple sclerosis.Acta neurologica Belgica · 2026Article
- The Relationship Between Subjective and Objective Fatigue Assessment Approaches in Multiple Sclerosis: A Meta-Analysis.Neuropsychology review · 2026Review
- Invisible symptoms and associated factors in multiple sclerosis patients.Journal of education and health promotion · 2026Article
- Investigation of the Relationship Between Serum Trace Elements and MSFC Levels in Multiple Sclerosis: A Cross-sectional Case-Control Study.Biological trace element research · 2025Article
- The periodontal pathogen Fusobacterium nucleatum is associated with disease severity in multiple sclerosis.Scientific reports · 2025Article
- Understanding use and predictors of compensatory cognitive strategies in people with multiple sclerosis.Multiple sclerosis and related disorders · 2025Article
- Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.Annals of medicine and surgery (2012) · 2025Review
- The influence of information processing speed on memory processes in patients with relapsing-remitting and primary progressive multiple sclerosis.Scientific reports · 2025Article
- Association between CD20European journal of neurology · 2025Article
- The presence and burden of cognitive issues: discordance between the perception of neurologists and people living with multiple sclerosis.European journal of neurology · 2025Article
- The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis.Arquivos de neuro-psiquiatria · 2024Article
- The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis.Journal of neurology · 2024Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Depression and anxiety in multiple sclerosis. Review of a fatal combination.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study.Neuro-oncology practice · 2024Article
- Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety.Neurology research international · 2024Article
- The relation between the symbol digit modalities test, fatigue, depression, and anxiety symptoms in a Belgian MS cohort.Acta neurologica Belgica · 2023Article
- Establishing the consistency of a voice recognition symbol digit modalities test analogue.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration.Behavioral sciences (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is a chronic, progressive, and neurodegenerative central nervous system disorder. MS usually causes disability, cognitive deficiency, fatigue, and depression symptoms.
objectivesTo assess cognitive functions of people with MS (pwMS) and investigate the impact of depression, fatigue, and disability on cognitive functions.
methodsWe administered the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery to assess 200 pwMS. The Expanded Disability Status Scale (EDSS) was used to evaluate disability levels. Fatigue Severity Scale (FSS) and the Beck Depression Inventory (BDI) were used, respectively, for fatigue and depression levels.
resultsEDSS and FSS scores were significantly higher in those with a disease duration of 5 years or more. Those with the EDSS ≥ 4 were found to have lower BICAMS performances and higher FSS scores. There was a significant difference in Symbol Digit Modalities Test (SDMT) performances between the groups with and without fatigue (FSS ≥ 4 and FSS < 4, respectively). When depression and fatigue symptoms concur or in the existence of just one of them or none of them, significant differences in terms of SDMT performances have been shown.
conclusionThe level of disability and fatigue adversely affects the cognitive functions of pwMS; depression has no significant effect. BICAMS that is specific for MS can be beneficial to assess the cognitive state of pwMS.
Indexed as
Identifiers
33006048What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.