Evidence map›Paper›PMID 33005996›Full record

ArticleJournal of medical systems2020

Towards the Probabilistic Analysis of Small Bowel Capsule Endoscopy Features to Predict Severity of Duodenal Histology in Patients with Villous Atrophy.

Stefania Chetcuti Zammit, Lawrence A Bull, David S Sanders, Jessica Galvin, Nikolaos Dervilis, Reena Sidhu, Keith Worden

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical systems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Cellular and molecular basis of proximal small intestine disorders.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Stefania Chetcuti ZammitAcademic Unit, Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK. stf_che@yahoo.com.ORCID https://orcid.org/0000-0002-1361-2204
Lawrence A BullDynamics Research Group, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.
David S SandersAcademic Unit, Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK.
Jessica GalvinBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nikolaos DervilisDynamics Research Group, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.
Reena SidhuAcademic Unit, Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK.
Keith WordenDynamics Research Group, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.
University of Sheffield · GBSheffield Teaching Hospitals NHS Foundation Trust · GBQueen Mary University of London · GBRoyal Hallamshire Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small bowel capsule endoscopy (SBCE) can be complementary to histological assessment of celiac disease (CD) and serology negative villous atrophy (SNVA). Determining the severity of disease on SBCE using statistical machine learning methods can be useful in the follow up of patients. SBCE can play an additional role in differentiating between CD and SNVA. De-identified SBCEs of patients with CD and SNVA were included. Probabilistic analysis of features on SBCE were used to predict severity of duodenal histology and to distinguish between CD and SNVA. Patients with higher Marsh scores were more likely to have a positive SBCE and a continuous distribution of macroscopic features of disease than those with lower Marsh scores. The same pattern was also true for patients with CD when compared to patients with SNVA. The validation accuracy when predicting the severity of Marsh scores and when distinguishing between CD and SNVA was 69.1% in both cases. When the proportions of each SBCE class group within the dataset were included in the classification model, to distinguish between the two pathologies, the validation accuracy increased to 75.3%. The findings of this work suggest that by using features of CD and SNVA on SBCE, predictions can be made of the type of pathology and the severity of disease.

Indexed as

Capsule EndoscopyCeliac DiseaseAtrophyDuodenumHumansCeliac diseaseDuodenal histologyProbabilistic analysisSeronegative villous atrophySmall bowel capsule endoscopy

Identifiers

PMID33005996
PMCPMC7529615
OpenAlexW3090695783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.