Evidence map›Paper›PMID 33005982›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Clear cell sarcoma-like/malignant gastrointestinal neuroectodermal tumor of the tongue: a clinicopathologic and molecular case report.

Marta Sbaraglia, Lucia Zanatta, Luisa Toffolatti, Andrea Spallanzani, Federica Bertolini, Francesco Mattioli, Federico Lami, Livio Presutti, Angelo P Dei Tos

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Marta SbaragliaDepartment of Pathology, Azienda Ospedale Università Padova, Padua, Italy. marta.sbaraglia@unipd.it.
Lucia ZanattaDepartment of Pathology, Azienda ULSS N. 2 Marca Trevigiana, Treviso, Italy.
Luisa ToffolattiDepartment of Pathology, Azienda ULSS N. 2 Marca Trevigiana, Treviso, Italy.
Andrea SpallanzaniDepartment of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
Federica BertoliniDepartment of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
Francesco MattioliOtorhinolaryngology Head and Neck Surgery Department, University Hospital of Modena, Modena, Italy.
Federico LamiOtorhinolaryngology Head and Neck Surgery Department, University Hospital of Modena, Modena, Italy.
Livio PresuttiOtorhinolaryngology Head and Neck Surgery Department, University Hospital of Modena, Modena, Italy.
Angelo P Dei TosDepartment of Pathology, Azienda Ospedale Università Padova, Padua, Italy.ORCID http://orcid.org/0000-0002-1228-8940
University of Modena and Reggio Emilia · ITAULSS 2 Marca Trevigiana · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant gastrointestinal neuroectodermal tumor (M-GNET) and clear cell sarcoma (CCS) of soft tissue represent closely related, extremely rare, malignant mesenchymal neoplasm of uncertain differentiation. Both entities are characterized genetically by the same molecular alterations represented by the presence of EWSR1-ATF1 and, more rarely, EWSR1-CREB1 fusion genes. The latter translocation seems to be more represented in M-GNET that, despite significant morphologic overlap with CCS, tends to lack overt features of melanocytic differentiation. Most M-GNET occur in the lower gastrointestinal tract, whereas occurrence in the upper tract has been reported only exceptionally. The differential diagnosis represents a major challenge, and accurate diagnosis impact significantly on therapeutic planning. We herein report the clinicopathologic features of a molecularly confirmed M-GNET that arose at the base of the tongue and review the pertinent literature.

Indexed as

Biomarkers, TumorCalmodulin-Binding ProteinsDiagnosis, DifferentialFemaleGastrointestinal NeoplasmsHumansMiddle AgedNeuroectodermal TumorsSarcoma, Clear CellTranslocation, GeneticBiomarkers, TumorCalmodulin-Binding ProteinsClear cell sarcomaMalignant gastrointestinal neuroectodermal tumorNext-generation sequencingOral cavity

Identifiers

PMID33005982
OpenAlexW3089840684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.