Evidence map›Paper›PMID 33005951›Full record

ArticleInternational journal of epidemiology2020

Accumulation of childhood adversities and type 1 diabetes risk: a register-based cohort study of all children born in Denmark between 1980 and 2015.

Jessica Bengtsson, Stine Byberg, Bendix Carstensen, Bianca L De Stavola, Jannet Svensson, Marit E Jørgensen, Naja H Rod

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jessica BengtssonClinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Stine BybergClinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Bendix CarstensenClinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Bianca L De StavolaGreat Ormond Street Institute of Child Health, University College London, London, UK.
Jannet SvenssonDepartment of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Herlev, Denmark.
Marit E JørgensenClinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Naja H RodSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Steno Diabetes Centers · DKUniversity of Copenhagen · DKCopenhagen University Hospital · DKGreat Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have indicated an association between childhood adversities and type 1 diabetes but have been underpowered and limited by selection. We aim to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk, and to assess whether the effect differs between males and females in a large and unselected population sample.

methodsWe used register-based data covering all children born in Denmark between 1980 and 2015, totalling >2 million children. We specified a multi-state model to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk. The effects of specific childhood adversities on type 1 diabetes were estimated using proportional hazards models.

resultsAccumulation of childhood adversities had a quantitatively small effect on type 1 diabetes risk among females [adjusted hazard ratio (HR) per adversity increase: 1.07; 95% confidence interval (CI): 1.02-1.11], but not among males (adjusted HR per adversity increase: 0.99; 95% CI: 0.97-1.03). Females exposed to extreme numbers (7+) of adversities had two times higher risk of type 1 diabetes compared with unexposed females (adjusted HR: 2.06; 95% CI: 1.10-3.86).

conclusionsIn an unselected total population sample, we generally find no or negligible effects of childhood adversities on type 1 diabetes risk, which may be reassuring to persons with type 1 diabetes who are concerned that personal trauma contributed to their disease. There is a very small group of females exposed to a high degree of adversity who may have a higher risk of type 1 diabetes and this group needs further attention.

Indexed as

Diabetes Mellitus, Type 1ChildCohort StudiesDenmarkFemaleHumansLife Change EventsMaleRisk Factorsadverse childhood experienceschildhood adversitiesLife courselife eventsprospective studyregister-basedtype 1 diabetes

Identifiers

PMID33005951
PMCPMC7746411
OpenAlexW3089942270

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.