ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Significantly Lower Case-fatality Ratio of Coronavirus Disease 2019 (COVID-19) than Severe Acute Respiratory Syndrome (SARS) in Hong Kong-A Territory-Wide Cohort Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Improving case fatality ratio estimates in ongoing pandemics through case-to-death time distribution analysis.Scientific reports · 2025Article
- The association between baseline viral load and long-term risk in patients with COVID-19 in Hong Kong: a territory-wide study.Scientific reports · 2024Article
- Risk prediction of advanced colorectal neoplasia among diabetic patients: A derivation and validation study.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- COVID-19-Induced Diabetes Mellitus: Comprehensive Cellular and Molecular Mechanistic Insights.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Aggravated pneumonia and diabetes in SARS-CoV-2 infected diabetic mice.Emerging microbes & infections · 2023Article
- Comparison of the 12-month impact of COVID-19 and SARS on physiological capacity and health-related quality of life.BMC pulmonary medicine · 2023Article
- Prediction algorithm for gastric cancer in a general population: A validation study.Cancer medicine · 2023Article
- Evolution of SARS-CoV-2 Variants: Implications on Immune Escape, Vaccination, Therapeutic and Diagnostic Strategies.Viruses · 2023Review
- Clinical Outcomes Following Treatment for COVID-19 With Nirmatrelvir/Ritonavir and Molnupiravir Among Patients Living in Nursing Homes.JAMA network open · 2023Article
- Incidence of Viral Rebound After Treatment With Nirmatrelvir-Ritonavir and Molnupiravir.JAMA network open · 2022Article
- Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022Review
- Glucose-lowering drugs and outcome from COVID-19 among patients with type 2 diabetes mellitus: a population-wide analysis in Hong Kong.BMJ open · 2021Article
- Hospital mortality in patients with rare diseases during pandemics: lessons learnt from the COVID-19 and SARS pandemics.Orphanet journal of rare diseases · 2021Article
- Differential Impacts of Multimorbidity on COVID-19 Severity across the Socioeconomic Ladder in Hong Kong: A Syndemic Perspective.International journal of environmental research and public health · 2021Article
- Insulin resistance in COVID-19 and diabetes.Primary care diabetes · 2021Review
- Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells.Cell death discovery · 2021Article
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Abstract
backgroundThe case-fatality ratios (CFR) of coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) appeared to differ substantially. We aimed to compare the CFR and its predictors of COVID-19 and SARS patients using a territory-wide cohort in Hong Kong.
methodsThis was a territory-wide retrospective cohort study using data captured from all public hospitals in Hong Kong. Laboratory-confirmed COVID-19 and SARS patients were identified. The primary endpoint was a composite endpoint of intensive care unit admission, use of mechanical ventilation, and/or death.
resultsWe identified 1013 COVID-19 patients (mean age, 38.4 years; 53.9% male) diagnosed from 23 January to 14 April 2020 and 1670 SARS patients (mean age, 44.4 years; 44.0% male) from March to June 2003. Fifty-five (5.4%) COVID-19 patients and 432 (25.9%) SARS patients had reached the primary endpoint in 30 days. By 30 June 2003, 286 SARS patients had died (CFR, 17.1%). By 7 June 2020, 4 COVID-19 patients had died (CFR, 0.4%). After adjusting for demographic and clinical parameters, COVID-19 was associated with a 71% lower risk of primary endpoint compared with SARS (adjusted hazard ratio, 0.29; 95% confidence interval, .21-.40; P < .0001). Age, diabetes mellitus, and laboratory parameters (high lactate dehydrogenase, high C-reactive protein, and low platelet count) were independent predictors of the primary endpoint in COVID-19 patients, whereas use of antiviral treatments was not associated with primary endpoint.
conclusionsThe CFR of COVID-19 was 0.4%. Age and diabetes were associated with worse outcomes, whereas antiviral treatments were not.
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