ArticleAnnals of gastroenterological surgery2020
A novel risk-scoring system for predicting lymph node metastasis of rectal neuroendocrine tumors.
Article in Annals of gastroenterological surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- NANETS Guidelines for the diagnosis and management of stage I-III rectal neuroendocrine tumors.Endocrine-related cancer · 2026Guideline
- Preoperative synthetic magnetic resonance imaging-based biomarkers for predicting tumor budding of rectal cancer.BMC medical imaging · 2026Article
- Short Distal Resection Margin Does Not Increase Recurrence Risk After R0 Resection for Rectal Neuroendocrine Tumors: A Single-Institution Retrospective Study of 208 Patients.Annals of gastroenterological surgery · 2026Article
- Current advances in neuroendocrine neoplasms of the colon and rectum.World journal of clinical oncology · 2025Review
- Current status of endoscopic resection for small rectal neuroendocrine tumors.World journal of gastroenterology · 2025Review
- Innovative approaches in predicting outcomes for rectal neuroendocrine tumors.World journal of gastroenterology · 2025Review
- Treatment indicators and prognostic factors in colorectal neuroendocrine neoplasms and adenocarcinoma with neuroendocrine differentiation: a single center retrospective study.International journal of colorectal disease · 2024Article
- Risk Factors for Lymph Node Metastasis of Rectal Neuroendocrine Tumor and Its Prognostic Impact: A Single-Center Retrospective Analysis of 195 Cases with Radical Resection.Annals of surgical oncology · 2023Article
- Efficacy of Endoscopic Resection for Rectal Neuroendocrine Tumors Smaller than 15 mm.Digestive diseases and sciences · 2023Article
- NEN Gain or NEN Loss: Endoscopic Resection for Rectal Neuroendocrine Neoplasms < 15 mm.Digestive diseases and sciences · 2023Article
- Review
- Endoscopic treatment and management of rectal neuroendocrine tumors less than 10 mm in diameter.World journal of gastrointestinal endoscopy · 2023Review
- Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.International journal of colorectal disease · 2023Article
- An update on the development of concepts, diagnostic criteria, and challenging issues for neuroendocrine neoplasms across different digestive organs.Virchows Archiv : an international journal of pathology · 2022Review
- Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms: The NOVARA Score, a Multicentre Retrospective Study.Journal of clinical medicine · 2022Article
- Tumor grade 2 as the independent predictor for lymph node metastasis in 10-20 mm sized rectal neuroendocrine tumor.Korean journal of clinical oncology · 2021Article
- A novel risk-scoring system for predicting lymph node metastasis of rectal neuroendocrine tumors.Annals of gastroenterological surgery · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough rectal neuroendocrine tumors (NETs) are considered to be rare low-grade malignancies when lymph node metastasis (LNM) is present, their degree of malignancy is comparable to that of colorectal cancer (CRC). However, it remains unclear as to which patients require radical lymph node dissection. The aim of this study was to elucidate the risk factors for LNM and develop a risk-scoring system for LNM to help determine appropriate therapeutic approaches.
methodsIn this study, we examined 103 patients with rectal NETs who underwent local resection (n = 55) or radical resection with LN dissection (n = 48). We evaluated each pathological feature, including the depth of submucosal invasion (SM depth) and tumor budding grade.
resultsAccording to our univariate analyses and previous reports, the significant five risk factors for LNM were weighted with point values: 2 points for tumor size ≥ 15 mm and muscularis invasion, and 1 point each for SM depth ≥ 2000 µm, positive lymphovascular invasion, budding grade 3, and vertical margin. The area under the receiver operating curve for the scoring system was 0.899 (95% CI: 0.843-0.955). When a score of 2 was used as the cut-off value, the sensitivity and specificity for the prediction of LNM were 100% and 72.1%, respectively.
conclusionsThe risk-scoring system for LNM of rectal NETs showed high diagnostic performance. Using this risk-scoring system, it is possible to predict the risk of LNM and thereby potentially avoid unnecessary surgery. Further prospective external validation studies should be performed. The study was registered in the Japanese Clinical Trials Registry as UMIN000036658.
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