ReviewClinical and translational radiation oncology2020
ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer.
Review in Clinical and translational radiation oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Experimental evaluation of an intraoperative-imaging based workflow for electron beam radiotherapy of pancreatic cancer using in situ dosimetry.Journal of applied clinical medical physics · 2026Article
- The Impact of Intraoperative Radiotherapy on Margin Positive Locally Advanced Rectal Cancer: A Propensity-Matched Analysis of The National Cancer Database.Journal of surgical oncology · 2025Article
- A Review on the Evolving Role of Radiation Therapy in the Treatment of Locally Advanced Rectal Cancer.Current oncology (Toronto, Ont.) · 2025Review
- Evaluation of RADIANCE Monte Carlo algorithm for treatment planning in electron based Intraoperative Radiotherapy (IOERT).Zeitschrift fur medizinische Physik · 2025Article
- Development and validation of a Monte Carlo model of a mobile accelerator for intraoperative radiation therapy.Medical physics · 2025Article
- Current and future perspectives in the management and treatment of colorectal cancer.World journal of clinical oncology · 2025Article
- Article
- Comparative safety and short-term outcomes of intraoperative radiotherapy versus neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a retrospective study.Frontiers in surgery · 2025Article
- The Role of Intraoperative Radiotherapy Treatment of Locally Advanced Rectal Cancer.Clinics in colon and rectal surgery · 2024Review
- Post-operative complications following dose adaptation of intra-operative electron beam radiation therapy in locally advanced or recurrent rectal cancer.Journal of contemporary brachytherapy · 2024Article
- First clinical application of image-guided intraoperative electron radiation therapy with real time intraoperative dose calculation in recurrent rectal cancer: technical procedure.Radiation oncology (London, England) · 2023Article
- Inorganic Nanoparticles as Radiosensitizers for Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2023Review
- Article
- Clinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical development.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Validation of Monte Carlo-based calculations for megavolt electron beams for IORT and FLASH-IORT.Heliyon · 2022Article
- Narrowing the difference in dose delivery for IOERT and IOBT for locally advanced and locally recurrent rectal cancer.Journal of contemporary brachytherapy · 2022Article
- Review
- Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.Nature reviews. Clinical oncology · 2022Review
- Article
- Reporting quality of practice guidelines on colorectal cancer: evaluation using the RIGHT reporting checklist.Annals of translational medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as "locally advanced", there is also variability in the extent of disease with no uniform definition of resectability. A practice-oriented definition of a locally advanced tumour is a tumour that cannot be resected without leaving microscopic or gross residual disease at the resection site. Since these patients do poorly with surgery alone, irradiation and chemotherapy have been added to improve the outcome. Intraoperative irradiation (IORT) is a component of local treatment intensification with favourable results in this subgroup of patients. International guidelines (National Comprehensive Cancer Network (NCCN) guidelines) currently recommend the use of IORT for rectal cancer resectable with very close or positive margins, especially for T4 and recurrent cancers. We report the ESTRO-ACROP (European Society for Radiotherapy and Oncology - Advisory Committee on Radiation Oncology Practice) recommendations for performing IORT in primary locally advanced rectal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.