Evidence map›Paper›PMID 33005739›Full record

ArticleBioengineering & translational medicine2020

The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles.

Yi Huang, Kairui Jiang, Xuting Zhang, Eun Ji Chung

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
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  7. Review
  8. Nanoparticles in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026
    Review
  9. Ultrabright NIR-II Nanoprobes forACS nanoscience Au · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions.Journal of the American Society of Nephrology : JASN · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Efficient and selective kidney targeting by chemically modified carbohydrate conjugates.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  20. Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yi HuangDepartment of Biomedical Engineering University of Southern California Los Angeles California USA.
Kairui JiangDepartment of Biomedical Engineering University of Southern California Los Angeles California USA.
Xuting ZhangDepartment of Biomedical Engineering University of Southern California Los Angeles California USA.
Eun Ji ChungDepartment of Biomedical Engineering University of Southern California Los Angeles California USA.ORCID https://orcid.org/0000-0002-7726-5555
University of Southern California · US

Funding

A Revolutionary Approach for Polycystic Kidney Disease: Oral NanotherapeuticsDP2DK121328 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUNG, EUN JI PAIGE · 2018 to 2018
$2.4M
Multimodal Peptide Amphiphile Micelles for AtherosclerosisR00HL124279 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUNG, EUN JI PAIGE · 2016 to 2018
$747k
NHLBI NIH HHS R00 HL124279NIDDK NIH HHS DP2 DK121328
6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects 15% of the US adult population. However, most clinically available drugs for CKD show low bioavailability to the kidneys and non-specific uptake by other organs which results in adverse side effects. Hence, a targeted, drug delivery strategy to enhance kidney drug delivery is highly desired. Recently, our group developed small, organic nanoparticles called peptide amphiphile micelles (PAM) functionalized with the zwitterionic peptide ligand, (KKEEE)

Indexed as

chronic kidney diseasemicellenanoparticlepeptiderenal clearance

Identifiers

PMID33005739
PMCPMC7510478
OpenAlexW3044546532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.