Evidence map›Paper›PMID 33005737›Full record

ArticleBioengineering & translational medicine2020

The wasp venom antimicrobial peptide polybia-CP and its synthetic derivatives display antiplasmodial and anticancer properties.

Marcelo D T Torres, Adriana F Silva, Gislaine P Andrade, Cibele N Pedron, Giselle Cerchiaro, Anderson O Ribeiro, Vani X Oliveira, Cesar de la Fuente-Nunez

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Immunobiological mechanisms of action of oncolytic peptides.Journal for immunotherapy of cancer · 2026
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  8. Short Fragmented Peptides fromCurrent drug discovery technologies · 2024
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  9. Article
  10. Review
  11. Review
  12. Bioactive Peptides against Human Apicomplexan Parasites.Antibiotics (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. BioTM Buzz (Volume 5, Issue 3): The Future is Bright.Bioengineering & translational medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Marcelo D T TorresMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Penn Institute for Computational Science, and Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA.ORCID https://orcid.org/0000-0002-6165-9138
Adriana F SilvaCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Gislaine P AndradeCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Cibele N PedronCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Giselle CerchiaroCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Anderson O RibeiroCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Vani X OliveiraCentro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André SP Brazil.
Cesar de la Fuente-NunezMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Penn Institute for Computational Science, and Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA.ORCID https://orcid.org/0000-0002-2005-5629
Universidade Federal do ABC · BRTranslational Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wasp venom-derived antimicrobial peptide polybia-CP has been previously shown to exhibit potent antimicrobial activity, but it is also highly toxic. Previously, using a physicochemical-guided peptide design strategy, we reversed its toxicity while preserving and even enhancing its antibacterial properties. Here, we report on several additional unanticipated biological properties of polybia-CP and derivatives, namely their ability to target

Indexed as

antimicrobial peptidesPolybia‐CPrational designstructure‐guided designwasp venom peptide

Identifiers

PMID33005737
PMCPMC7510464
OpenAlexW3024953354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.