ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Exploring the genetic relationship between hearing impairment and Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Reductions in brainstem volume as a key macrostructural indicator in at-risk populations for Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.Human brain mapping · 2025Article
- Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.Alzheimer's research & therapy · 2024Article
- Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating the Shared Genetic Etiology Between Parkinson's Disease and Depression.Journal of Parkinson's disease · 2024Article
- Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk.NPJ Parkinson's disease · 2023Article
- Hearing loss and its link to cognitive impairment and dementia.Frontiers in dementia · 2023Review
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- No Influence of Age-Related Hearing Loss on Brain Amyloid-β.Journal of Alzheimer's disease : JAD · 2022Article
- Hearing loss and brain disorders: A review of multiple pathologies.Open medicine (Warsaw, Poland) · 2022Review
- Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Hardware-efficient auto-reconfigurable hearing aids using 3-level octave interpolated filters for auditory compensation applications.Physical and engineering sciences in medicine · 2021Article
- Hearing difficulty is linked to Alzheimer's disease by common genetic vulnerability, not shared genetic architecture.NPJ aging and mechanisms of disease · 2021Article
- Hearing Impairment and Cognition in an Aging World.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Hearing Loss and Cognition: What We Know and Where We Need to Go.Frontiers in aging neuroscience · 2021Review
- Exploring the genetic relationship between hearing impairment and Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Computerized cognitive testing to capture cognitive decline in Alzheimer's disease: Longitudinal findings from the ARMADA study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionHearing loss has been identified as the potentially largest modifiable risk factor for Alzheimer's disease (AD), estimated to account for a similar increase in AD risk as the apolipoprotein E (
methodsWe investigated the genetic relationship between hearing loss and AD, and sought evidence for a causal relationship.
resultsWe found a significant genetic overlap between hearing impairment and AD and a polygenic risk score for AD was able to significantly predict hearing loss in an independent cohort. Additionally, regions of the genome involved in inflammation were identified to be shared between hearing difficulty and AD. However, causality tests found no significant evidence of a causal relationship between these traits in either direction. DISCUSSION: Overall, these results show that the relationship between hearing difficulty and AD may, in part, be due to shared genes and immune response pathways between the traits. However, currently available data do not support a causal relationship.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.