Evidence map›Paper›PMID 33005700›Full record

ArticleOpen forum infectious diseases2020

Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection.

Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Neuroimaging the Neuropathogenesis of HIV.Current HIV/AIDS reports · 2021
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Catherine W CaiHIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Suteeraporn PinyakornHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Eugène KroonSouth East Asia Research Collaboration in HIV (SEARCH), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Mark de SouzaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Donn J ColbyHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Tippawan PankamThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Supanit PattanachaiwitThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Sasiwimol UbolyamThe HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Adam RupertLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Perrine LallemandLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Robin DewarLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Helene C HighbargerLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Jintanat AnanworanichHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Sandhya VasanHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Irini SeretiHIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0076-0224
Henry M. Jackson Foundation · USLeidos (United States) · USHIV Netherlands Australia Thailand Research Collaboration · THNational Institutes of Health · USThai Red Cross Society · TH

Funding

CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH.

Indexed as

AIDSchronic inflammationcoagulopathyHIVviral reservoir

Identifiers

PMID33005700
PMCPMC7519777
OpenAlexW3080647756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.