Evidence map›Paper›PMID 33005613›Full record

ArticleOcular oncology and pathology2020

Long-Term Clinical Results and Management following Vitrectomy in Undetected Retinoblastoma Eyes.

Eva Biewald, Sabrina Schlüter, Nikolaos E Bechrakis, Tobias Kiefer, Philipp Rating, Dirk Geismar, Klaus A Metz, Sophia Göricke, Petra Ketteler, Norbert Bornfeld

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In one paragraph

Article in Ocular oncology and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. [Liquid biopsy in retinoblastomas].Die Ophthalmologie · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eva BiewaldDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sabrina SchlüterDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Nikolaos E BechrakisDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Tobias KieferDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Philipp RatingDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Dirk GeismarWest German Proton Therapy Centre, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Klaus A MetzInstitute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sophia GörickeDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Petra KettelerDepartment of Haematology/Oncology, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Norbert BornfeldDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGiven the rarity of retinoblastoma and the consequences of accidental vitrectomy in the event of misdiagnosis, reporting on clinical experience in this area is important.

objectiveThe aim of this study was to analyse the management and complications with a focus on local orbital recurrence and metastatic disease in 10 children vitrectomized in an undetected retinoblastoma eye.

methodsThis is a retrospective descriptive case series conducted in a single-centre referral university hospital.

resultsFrom October 1991 to June 2019, 10 patients with a vitrectomy in an unsuspected retinoblastoma eye were included in this study. The main preoperative diagnoses were unilateral inflammation with a suspected lymphoma, uveitis or toxocariasis in 5 cases, vitreous haemorrhage after trauma in 2 cases, and the last 3 were misdiagnosed with Coats disease, rhegmatogenous retinal detachment and congenital cataract. Mean age at surgery was 3 years, ranging from 14 months to 6 and a half years. Nine patients were suffering from unilateral retinoblastoma; these were enucleated and treated with 4-6 cycles of chemotherapy and/or radiation therapy. The sclerotomy sites were infiltrated with tumour cells in 3 cases. In 1 patient, the differential diagnosis of a malignant medulloepithelioma could not be excluded. One patient had bone marrow infiltration on initial presentation; all other patients are healthy without any signs of orbital recurrence or metastatic disease with a mean follow-up of 5.4 years.

conclusionIn children, intraocular tumours, including retinoblastoma and medulloepithelioma, should be ruled out before pars plana vitrectomy is performed. If no doubtless preoperative diagnosis can be established, preoperative magnetic resonance imaging is mandatory. If a vitrectomy in a retinoblastoma eye has been performed, immediate enucleation of the eye with subsequent chemotherapy and orbital radiation is effective to avoid local recurrence and systemic metastases.

Indexed as

Adjuvant radiotherapyEnucleationIatrogenic tumour cell spreadMasquerade syndromeMetastatic diseaseSystemic chemotherapy

Identifiers

PMID33005613
PMCPMC7506289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.