Evidence map›Paper›PMID 33005568›Full record

ArticleToxicology reports2020

In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning.

Shawn Owiredu, Abhay Ranganathan, John C Greenwood, Sarah Piel, Joanna I Janowska, David M Eckmann, Matthew Kelly, Johannes K Ehinger, Todd J Kilbaugh, David H Jang

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Blood Cells as a Cellular Biomarker for Mitochondrial Function in a Experimental Model of Acute Carbon Monoxide Poisoning with Treatment.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025
    Article
  2. Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  3. Cell-Free DNA as a Biomarker in a Rodent Model of Chlorpyrifos Poisoning Causing Mitochondrial Dysfunction.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Article
  4. Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Article
  5. Article
  6. Article
  7. Emerging cellular-based therapies in carbon monoxide poisoning.American journal of physiology. Cell physiology · 2021
    Review
  8. Landing a Successful R or K Grant: a Young Investigator's Journey.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shawn OwireduDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Abhay RanganathanChildren's Hospital of Philadelphia (CHOP), Philadelphia, PA, 19104, United States.
John C GreenwoodDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Sarah PielChildren's Hospital of Philadelphia (CHOP), Philadelphia, PA, 19104, United States.
Joanna I JanowskaChildren's Hospital of Philadelphia (CHOP), Philadelphia, PA, 19104, United States.
David M EckmannDepartment of Anesthesiology and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Matthew KellyDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Johannes K EhingerChildren's Hospital of Philadelphia (CHOP), Philadelphia, PA, 19104, United States.
Todd J KilbaughChildren's Hospital of Philadelphia (CHOP), Philadelphia, PA, 19104, United States.
David H JangDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to compare the use of hydroxocobalamin (B12a) and a succinate prodrug to evaluate for improvement in mitochondrial function in an

Indexed as

AntidoteCyanideMitochondriaRespiration

Identifiers

PMID33005568
PMCPMC7511654
OpenAlexW3087121893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.