Evidence map›Paper›PMID 33005468›Full record

ArticleCase reports in pathology2020

Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature.

Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Multifocal medulloblastoma in an adult: a case report and review of the literature.Journal of cancer research and clinical oncology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Irene TronconDepartment of Neurosurgery, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
Angela GuerrieroDepartment of Pathology and Molecular Genetics, Treviso General Hospital, Treviso, Italy.ORCID https://orcid.org/0000-0001-9981-7448
Sabrina RossiDepartment of Pathology, Bambino Gesù Children's Hospital, Rome, Italy.
Monica RonzonDepartment of Neuroradiology, Treviso Regional Hospital, Treviso, Italy.
Marta PadovanDepartment of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
Caccese MarioDepartment of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
Lucia ZanattaDepartment of Pathology and Molecular Genetics, Treviso General Hospital, Treviso, Italy.
Luisa ToffolattiDepartment of Pathology and Molecular Genetics, Treviso General Hospital, Treviso, Italy.
Elisabetta MartonDepartment of Neurologic Surgery, Treviso Regional Hospital, Treviso, Italy.
Giuseppe LombardiDepartment of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
Angelo Paolo Dei TosDepartment of Pathology and Molecular Genetics, Treviso General Hospital, Treviso, Italy.
Giuseppe CanovaDepartment of Neurologic Surgery, Treviso Regional Hospital, Treviso, Italy.
Ca' Foncello Hospital · ITIstituto Oncologico Veneto · ITBambino Gesù Children's Hospital · ITOspedale Santa Maria della Misericordia di Rovigo · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors. Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions. The histopathological analysis revealed different variants of medulloblastoma in the excised nodules, one being extensive nodularity, rare in adults, and the other desmoplastic/nodular with areas of anaplasia. Immunostains and molecular analysis classified both nodules as SHH medulloblastoma. Adult medulloblastoma is extremely rare. Important differences exist between adult medulloblastoma and medulloblastoma arising in children and infants. Such differences are in location, distribution of histological variants and of molecular subgroups, survival rates, and therapeutic options. An extensive morphological and molecular characterization of such rare tumors is necessary to choice the best-tailored therapy.

Identifiers

PMID33005468
PMCPMC7503105
OpenAlexW3085543155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.