Evidence map›Paper›PMID 33005416›Full record

ArticleClinical & translational immunology2020

Human

Rekha R Rapaka, Rezwanul Wahid, Stephanie Fresnay, Jayaum S Booth, Thomas C Darton, Claire Jones, Claire S Waddington, Myron M Levine, Andrew J Pollard, Marcelo B Sztein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Rekha R RapakaCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
Rezwanul WahidCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
Stephanie FresnayCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
Jayaum S BoothCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
Thomas C DartonOxford Vaccine Group Department of Paediatrics University of Oxford and the NIHR Oxford Biomedical Research Centre Oxford UK.
Claire JonesOxford Vaccine Group Department of Paediatrics University of Oxford and the NIHR Oxford Biomedical Research Centre Oxford UK.
Claire S WaddingtonOxford Vaccine Group Department of Paediatrics University of Oxford and the NIHR Oxford Biomedical Research Centre Oxford UK.
Myron M LevineCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
Andrew J PollardOxford Vaccine Group Department of Paediatrics University of Oxford and the NIHR Oxford Biomedical Research Centre Oxford UK.
Marcelo B SzteinCenter for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA.
University of Maryland, Baltimore · USOxford BioMedica (United Kingdom) · GBUniversity of Oxford · GB

Funding

Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRASER, CLAIRE M. · 2009 to 2018
$27.8M
Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Probiotic yeast secreting single-domain antibodies to prevent Clostridium difficile and Campylobacter jejuni diseaseU19AI142725 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2019 to 2023
$12.5M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
FELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4M
Human Cellular Immune Programming Against Invasive SalmonellaK08AI143923 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAPAKA, REKHA R · 2019 to 2023
$798k
NIAID NIH HHS K08 AI143923NIAID NIH HHS R01 AI036525NIAID NIH HHS T32 AI007524NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI109776NIAID NIH HHS U19 AI142725Wellcome Trust
6 · The paper itself

Abstract

objectiveThere are no vaccines for most of the major invasive

methodsT memory cells from eleven volunteers who underwent controlled oral challenge with

resultsBlood T-cell effector memory (T

conclusionGaps in cross-reactive immune effector functions in human T-cell memory compartments were highly dependent on invasive

Indexed as

human challengeiNTSinvasive SalmonellaParatyphiS. TyphiT‐cell memory

Identifiers

PMID33005416
PMCPMC7512505
OpenAlexW3089317755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.