Evidence map›Paper›PMID 33005401›Full record

ArticleCancer & metabolism2020

Disruption of redox homeostasis for combinatorial drug efficacy in

Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cancer & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Daniela GaglioInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.ORCID 0000-0003-1217-7703
Marcella BonanomiISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Silvia ValtortaInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.
Rohit BharatISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Marilena RipamontiInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.
Federica ConteISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Giulia FisconISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Nicole RighiISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Elisabetta NapodanoInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.
Federico PapaISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Isabella RaccagniInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.
Seth J ParkerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA USA.
Ingrid CifolaInstitute for Biomedical Technologies (ITB), National Research Council (CNR), Segrate, Milan, Italy.
Tania CamboniInstitute for Biomedical Technologies (ITB), National Research Council (CNR), Segrate, Milan, Italy.
Paola PaciISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Anna Maria ColangeloISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Marco VanoniISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
Christian M MetalloDepartment of Bioengineering, University of California, San Diego, La Jolla, CA USA.
Rosa Maria MorescoInstitute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI Italy.
Lilia AlberghinaISBE. IT/Centre of Systems Biology, Piazza della Scienza 4, 20126 Milan, Italy.
University of Milano-Bicocca · ITInstitute of Molecular Bioimaging and Physiology · ITNational Research Council · ITInstitute of Biomedical Technologies · ITUniversity of California San Diego · USVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstract

backgroundRewiring of metabolism induced by oncogenic

methodsWe performed mass spectrometric metabolomics analysis in vitro and in vivo experiments to evaluate the efficacy of drugs and identify metabolic connectivity.

resultsWe show that

conclusionsOur findings open the way to develop metabolic connectivity profiling as a tool for a selective strategy of combined drug repositioning in precision oncology.

Indexed as

Combinatorial drug treatmentGlutamineGlycolysisMetabolic cancer therapyMetabolic connectivityMetabolic rewiringMetabolic signaturePrecision oncology

Identifiers

PMID33005401
PMCPMC7523077
OpenAlexW3091615802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.