Evidence map›Paper›PMID 33005170›Full record

ArticleFrontiers in genetics2020

The Profiling of DNA Methylation and Its Regulation on Divergent Tenderness in Angus Beef Cattle.

Chunping Zhao, Guanyu Ji, José A Carrillo, Yaokun Li, Fei Tian, Ransom L Baldwin, Linsen Zan, Jiuzhou Song

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Examining the extent of environmental contributions toward DNA methylation and phenotypic variation.Animal frontiers : the review magazine of animal agriculture · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chunping ZhaoCollege of Animal Science and Technology, Northwest A&F University, Xianyang, China.
Guanyu JiShenzhen GenDo Health Sci&Tech Ltd., Shenzhen, China.
José A CarrilloDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, United States.
Yaokun LiCollege of Animal Science and Technology, Northwest A&F University, Xianyang, China.
Fei TianDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, United States.
Ransom L BaldwinAnimal Genomics and Improvement Laboratory, BARC, NEA, USDA, Beltsville, MD, United States.
Linsen ZanCollege of Animal Science and Technology, Northwest A&F University, Xianyang, China.
Jiuzhou SongDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, United States.
University of Maryland, College Park · USNorthwest A&F University · CNAgricultural Research Service · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beef is an essential food source in the world. Beef quality, especially tenderness, has a significant impact on consumer satisfaction and industry profit. Many types of research to date have focused on the exploration of physiological and developmental mechanisms of beef tenderness. Still, the role and impact of DNA methylation status on beef tenderness have yet to be elucidated. In this study, we exhaustively analyzed the DNA methylation status in divergent tenderness observed in Angus beef. We characterized the methylation profiles related to beef tenderness and explored methylation distributions on the whole genome. As a result, differentially methylated regions (DMRs) associated with tenderness and toughness of beef were identified. Importantly, we annotated these DMRs on the bovine genome and explored bio-pathways of underlying genes and methylation biomarkers in beef quality. Specifically, we observed that the ATP binding cassette subfamily and myosin-related genes were highly methylated gene sets, and generation of neurons, regulation of GTPase activity, ion transport and anion transport,

Indexed as

beef qualityDMRDNA methylationepigeneticMBD-seq

Identifiers

PMID33005170
PMCPMC7479246
OpenAlexW3081287885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.