Evidence map›Paper›PMID 33005151›Full record

SynthesisFrontiers in psychiatry2020

Treatment Outcomes in Patients With Opioid Use Disorder Who Were First Introduced to Opioids by Prescription: A Systematic Review and Meta-Analysis.

Nitika Sanger, Meha Bhatt, Nikhita Singhal, Balpreet Panesar, Alessia D'Elia, Maegan Trottier, Hamnah Shahid, Alannah Hillmer, Natasha Baptist-Mohseni, Victoria Roczyki and 8 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Using Natural Language Processing of Clinical Notes to Predict Outcomes of Opioid Treatment Program.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Nitika SangerMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Meha BhattDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Nikhita SinghalUndergraduate MD Program, McMaster University, Hamilton, ON, Canada.
Balpreet PanesarLife Sciences Undergraduate Program, McMaster University, Hamilton, ON, Canada.
Alessia D'EliaDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Maegan TrottierDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
Hamnah ShahidArts & Sciences, McMaster University, Hamilton, ON, Canada.
Alannah HillmerDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
Natasha Baptist-MohseniDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
Victoria RoczykiDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Divya SoniHealth Sciences Undergraduate Program, McMaster University, Hamilton, ON, Canada.
Maurana BrushUndergraduate MD Program, McMaster University, Hamilton, ON, Canada.
Elizabeth LovellDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Stephanie SangerHealth Science Library, McMaster University, Hamilton, ON, Canada.
M Constantine SamaanDivision of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, ON, Canada.
Russell J de SouzaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Zainab SamaanDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
McMaster University · CAImpact · CAMcMaster Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrescription opioid misuse has led to a new cohort of opioid use disorder (OUD) patients who were introduced to opioids through a legitimate prescription. This change has caused a shift in the demographic profile of OUD patients from predominantly young men to middle age and older people. The management of OUD includes medication-assisted treatment (MAT), which produces varying rates of treatment response. In this study, we will examine whether the source of first opioid use has an effect on treatment outcomes in OUD. Using a systematic review of the literature, we will investigate the association between source of first opioid introduction and treatment outcomes defined as continuing illicit opioid use and poly-substance use while in MAT.

methodsMedline, EMBASE, CINHAL, and PsycInfo were searched from inception to December 31

resultsThe initial search results in 27,345 articles that were screened, and five observational studies were included in the qualitative and quantitative analyses. Our results found that those who were introduced to opioids through a legitimate prescription were significantly less likely to have illicit opioid use (0.70, 95% CI 0.50, 0.99) while on MAT. They were also less likely to use cannabis (0.54, 95% CI 0.32, 0.89), alcohol (0.75, 95% CI 0.59, 0.95), cocaine (0.50, 95% CI 0.29, 0.85), and injection drug use (0.25, 95% CI 0.14, 0.43) than those introduced to opioids through recreational means.

conclusionThis study shows that the first exposure to opioids, whether through a prescription or recreationally, influences prognosis and treatment outcomes of opioid use disorder. Although the increased pattern of prescribing opioids may have led to increased OUD in a new cohort of patients, these patients are less likely to continue to use illicit drugs and have a different prognostic and clinical profile that requires a tailored approach to treatment. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017058143.

Indexed as

meta-analysisopioidsopioid use disorderprescriptionsystematic review

Identifiers

PMID33005151
PMCPMC7485127
OpenAlexW3081925621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.