ArticleEye (London, England)2021
Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients.
Article in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Relevance of Arterial Blood Pressure in the Management of Glaucoma Progression: A Systematic Review.American journal of hypertension · 2024Pooled it
- Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma.International ophthalmology · 2026Review
- Changes in optic nerve head microvasculature following disc hemorrhage absorption in glaucomatous eyes.Scientific reports · 2025Article
- Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension.Journal of clinical medicine · 2024Article
- Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome.BMC ophthalmology · 2022Observational
- Association of choroidal blood flow with autonomic dysfunction in patients with normal tension glaucoma.Scientific reports · 2022Article
- Optical Coherence Tomography Angiography: Considerations Regarding Diagnostic Parameters.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between retinal microvascular structure and glaucoma has been revealed in multiple studies using optical tomography angiography (OCTA), but limited information on the macular vessel density (mVD) in patients with glaucoma is available. In this study, we tried to identity the factors that affected macular VD (mVD) in glaucomatous eyes.
methodsThis retrospective cross-sectional study evaluated OCT and OCTA images from 92 eyes from 58 healthy subjects and 179 eyes from 103 glaucoma patients using the SD-OCT database from July 2017 to July 2018. Glaucomatous eyes were further divided into two groups according to history of disc haemorrhage (DH). Association between mVD and demographic characteristics, ganglion cell-inner plexiform layer (GCIPL) thickness, visual field mean deviation (MD) and systemic blood pressure was analysed in each group.
resultsIn both healthy and glaucomatous eyes, mVD was inversely associated with age (β = -0.035, P = 0.025; β = -0.039, P = 0.018). In the glaucomatous eyes, mVD was significantly decreased, as the MD value was worse (β = 0.109, P = 0.002). In glaucomatous eyes with DH, mVD decreased as blood pressure increased (β = -0.111, P = 0.003)
conclusionsReduced mVD is more common in older individuals in both healthy and glaucomatous eyes, and correlates with functional deterioration than structural damage in glaucomatous eyes. In glaucomatous eyes with DH, high systemic BP is associated with a reduction in mVD. This may indicate that glaucoma patients with DH are more susceptible to vascular damage secondary to hypertension.
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