Evidence map›Paper›PMID 33005036›Full record

ReviewNature reviews. Nephrology2021

Challenges of access to kidney care for children in low-resource settings.

Mignon McCulloch, Valerie A Luyckx, Brett Cullis, Simon J Davies, Fredric O Finkelstein, Hui Kim Yap, John Feehally, William E Smoyer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 78 citations in OpenAlex.

  1. Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Are your kidneys okay? Detect early to protect kidney health.Kidney research and clinical practice · 2026
    Article
  7. Review
  8. Article
  9. Are your kidneys ok? Detect early to protect kidney health.Clinical and experimental nephrology · 2025
    Article
  10. Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  11. Are Your Kidneys Ok? Detect Early to Protect Kidney Health.American journal of hypertension · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Are Your Kidneys Ok? Detect Early to Protect Kidney Health.Canadian journal of kidney health and disease · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Mignon McCullochRed Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. mignon.mcculloch@uct.ac.za.ORCID http://orcid.org/0000-0003-2876-4785
Valerie A LuyckxInstitute of Biomedical Ethics and the History of Medicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7066-8135
Brett CullisPediatric and Adult Renal Units, University of Cape Town, Cape Town, South Africa.
Simon J DaviesFaculty of Medicine and Health Sciences, Keele University, Keele, UK.ORCID http://orcid.org/0000-0001-5127-4755
Fredric O FinkelsteinYale University, New Haven, CT, USA.
Hui Kim YapKhoo Teck Puat - National University Children's Medical Institute, National University Hospital, Kent Ridge, Singapore.
John FeehallyInternational Society of Nephrology, Brussels, Belgium.
William E SmoyerNationwide Children's Hospital, Columbus, OH, USA.
University of Cape Town · ZABrigham and Women's Hospital · USKeele University · GBKhoo Teck Puat Hospital · SGNationwide Children's Hospital · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney disease is a global public health concern across the age spectrum, including in children. However, our understanding of the true burden of kidney disease in low-resource areas is often hampered by a lack of disease awareness and access to diagnosis. Chronic kidney disease (CKD) in low-resource settings poses multiple challenges, including late diagnosis, the need for ongoing access to care and the frequent unavailability of costly therapies such as dialysis and transplantation. Moreover, children in such settings are at particular risk of acute kidney injury (AKI) owing to preventable and/or reversible causes - many children likely die from potentially reversible kidney disease because they lack access to appropriate care. Acute peritoneal dialysis (PD) is an important low-cost treatment option. Initiatives, such as the Saving Young Lives programme, to train local medical staff from low-resource areas to provide care for AKI, including acute PD, have already saved hundreds of children. Future priorities include capacity building for both educational purposes and to provide further resources for AKI management. As local knowledge and confidence increase, CKD management strategies should also develop. Increased awareness and advocacy at both the local government and international levels will be required to continue to improve the diagnosis and treatment of AKI and CKD in children worldwide.

Indexed as

Health Services AccessibilityAcute Kidney InjuryAdolescentChildChild, PreschoolCost-Benefit AnalysisDeveloping CountriesEarly DiagnosisEarly Medical InterventionGlomerulonephritisHealth ResourcesHealth WorkforceHumansImmunosuppressive AgentsKidney TransplantationNephrologyImmunosuppressive Agents

Identifiers

PMID33005036
OpenAlexW3090093367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.