ArticleScientific reports2020
Detection rate of diabetic macular microaneurysms comparing dye-based angiography and optical coherence tomography angiography.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- Clinical Performance of Semi-Automated Spectral-Domain Optical Coherence Tomography Angiography.Journal of clinical medicine · 2024Article
- Optical coherence tomography angiography for microaneurysms in anti-vascular endothelial growth factor treated diabetic macular edema.BMC ophthalmology · 2024Article
- Two cases of diabetic macular edema with diminished areas of retinal non-perfusion and microaneurysms after intravitreal faricimab injections.American journal of ophthalmology case reports · 2024Article
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Diabetic microaneurysms detected by fluorescein angiography spatially correlate with regions of macular ischemia delineated by optical coherence tomography angiography.Indian journal of ophthalmology · 2023Article
- Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy.Frontiers in ophthalmology · 2023Review
- Evaluation of microaneurysms as predictors of therapeutic response to anti-VEGF therapy in patients with DME.PloS one · 2022Article
- Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review.Biomedicines · 2021Review
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Diabetic maculopathy (DM) is a microvascular dysfunction clinically characterized by microaneurysms (MA) leading to edema and central visual deprivation. This prospective explorative study investigated 27 eyes of 17 patients with DM by fluorescein/indocyanine green angiography (FA/ICGA; SPECTRALIS HRA-OCT, Heidelberg Engineering) and by swept source-optical coherence tomography angiography (SS-OCTA; DRI-OCT Triton Plus, Topcon) to identify clinically relevant MAs. The SS-OCTA cubes were split into the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) according to the automated segmentation. The images of all modalities were superimposed for alignment by an Early Treatment Diabetic Retinopathy Study grid overlay and compared to each other. In total, the mean number of MAs in FA was 33.4 ± 22 (standard deviation) (median 27.5 [q1:21.75;q3:38.25]), in ICGA 24.9 ± 16.9 (17.5 [14;35]), in the SCP 6.5 ± 3.7 (5.5 [3.75;9.25]) and in the DCP 18.1 ± 10.5 (18.5 [10.75;23.5]). Mixed effects models between ICGA and the DCP were borderline significant (p = 0.048; 95% confidence interval 0.21 to 13.49), whereas all other imaging methods differed significantly. Quantitative analysis of MAs in DM showed a plausible agreement between ICGA and the DCP in SS-OCTA. These findings contribute to the imaging methodology in DM.
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