ArticleScientific reports2020
Myanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Two Decades of Melioidosis in India: A Comprehensive Epidemiological Review.Pathogens (Basel, Switzerland) · 2025Review
- Melioidosis cases detected in Dhaka, Bangladesh: a positive impact of 3rd South Asian melioidosis congress-2023.Current research in microbial sciences · 2025Article
- Genetic diversity, determinants, and dissemination of Burkholderia pseudomallei lineages implicated in melioidosis in Northeast Thailand.Nature communications · 2024Article
- Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia.PLoS neglected tropical diseases · 2024Article
- A systematic review and meta-analysis of the global prevalence and relationships amongVeterinary world · 2024Article
- Genetic diversity, determinants, and dissemination ofbioRxiv : the preprint server for biology · 2023Article
- Phylogeographic characterization of Burkholderia pseudomallei isolated from Bangladesh.PLoS neglected tropical diseases · 2023Article
- Melioidosis Queensland: An analysis of clinical outcomes and genomic factors.PLoS neglected tropical diseases · 2023Article
- Variable Virulence Genes in Clinical Isolates ofJournal of laboratory physicians · 2023Article
- Highly specific and sensitive detection of Burkholderia pseudomallei genomic DNA by CRISPR-Cas12a.PLoS neglected tropical diseases · 2022Article
- Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change.Current opinion in infectious diseases · 2022Review
- Genomic diversity of resistant and virulent factors ofFrontiers in microbiology · 2022Article
- Epidemiological and Clinical Characteristics of Melioidosis Caused by Gentamicin-SusceptibleOpen forum infectious diseases · 2021Article
- Observational study of adult respiratory infections in primary care clinics in Myanmar: understanding the burden of melioidosis, tuberculosis and other infections not covered by empirical treatment regimes.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Observational
- Enhanced melioidosis surveillance in patients attending four tertiary hospitals in Yangon, Myanmar.Epidemiology and infection · 2021Article
- Geographical distribution of Burkholderia pseudomallei in soil in Myanmar.PLoS neglected tropical diseases · 2021Article
- Genomic comparison and phenotypic profiling of small colony variants of Burkholderia pseudomallei.PloS one · 2021Article
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11 authors.
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Abstract
Melioidosis was first identified in Myanmar in 1911 but for the last century it has remained largely unreported there. Burkholderia pseudomallei was first isolated from the environment of Myanmar in 2016, confirming continuing endemicity. Recent genomic studies showed that B. pseudomallei originated in Australia and spread to Asia, with phylogenetic evidence of repeated reintroduction of B. pseudomallei across countries bordered by the Mekong River and the Malay Peninsula. We present the first whole-genome sequences of B. pseudomallei isolates from Myanmar: nine clinical and seven environmental isolates. We used large-scale comparative genomics to assess the genetic diversity, phylogeography and potential origins of B. pseudomallei in Myanmar. Global phylogenetics demonstrated that Myanmar isolates group in two distantly related clades that reside in a more ancestral Asian clade with high amounts of genetic diversity. The diversity of B. pseudomallei from Myanmar and divergence within our global phylogeny suggest that the original introduction of B. pseudomallei to Myanmar was not a recent event. Our study provides new insights into global patterns of B. pseudomallei dissemination, most notably the dynamic nature of movement of B. pseudomallei within densely populated Southeast Asia. The role of anthropogenic influences in both ancient and more recent dissemination of B. pseudomallei to Myanmar and elsewhere in Southeast Asia and globally requires further study.
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