Evidence map›Paper›PMID 33004930›Full record

ArticleScientific reports2020

Molecular targets for diagnostic and intraoperative imaging of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX treatment.

F A Vuijk, L D A N de Muynck, L C Franken, O R Busch, J W Wilmink, M G Besselink, B A Bonsing, S S Bhairosingh, P J K Kuppen, J S D Mieog and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Gut-to-tumor translocation of multidrug-resistantFrontiers in cellular and infection microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Advanced iron oxide nanotheranostics for multimodal and precision treatment of pancreatic ductal adenocarcinoma.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

F A VuijkDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
L D A N de MuynckDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
L C FrankenDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
O R BuschDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
J W WilminkDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
M G BesselinkDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
B A BonsingDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
S S BhairosinghDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
P J K KuppenDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
J S D MieogDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
C F M SierDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
A L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
J VerheijDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
A Fariňa-SarasquetaDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
R J SwijnenburgDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. r.j.swijnenburg@amsterdamumc.nl.
Leiden University Medical Center · NLUniversity of Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tissue and therapy induced fibrosis (TIF). Consequently, resections with tumor positive margins and subsequent early post-operative recurrences occur and patients eligible for potential radical resection could be missed. To optimize patient selection and monitor results of neoadjuvant treatment, PDAC-specific diagnostic and intraoperative molecular imaging methods are required. This study aims to evaluate molecular imaging targets for PDAC after neoadjuvant FOLFIRINOX treatment. Expression of integrin α

Indexed as

Intraoperative CareAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCarcinoma, Pancreatic DuctalFemaleFluorouracilFollow-Up StudiesHumansImage Processing, Computer-AssistedImmunohistochemistryIrinotecanLeucovorinMaleMiddle AgedNeoadjuvant TherapyOxaliplatinBiomarkers, TumorFluorouracilfolfirinoxIrinotecanLeucovorinOxaliplatin

Identifiers

PMID33004930
PMCPMC7529886
OpenAlexW3090414982

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.