ArticleScientific reports2020
Evidence of cortical thickness reduction and disconnection in high myopia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The Effect of Optic Nerve Crush on Lens-Induced Myopia in Mice.Ophthalmology science · 2026Article
- Cortical thickness and volume alterations in patients with high myopia: a magnetic resonance imaging study.BMC medical imaging · 2026Article
- Multilayer network analysis of dynamic network reconfiguration in age-related hearing loss: a cross-sectional case-control study.Quantitative imaging in medicine and surgery · 2025Article
- Cortical functional and structural alterations in rhegmatogenous retinal detachment: a multimodal analysis using surface-based independent component analysis, morphometry, and machine learning.Quantitative imaging in medicine and surgery · 2025Article
- Myopia in Beagles in a Family of 12 Individuals.Animals : an open access journal from MDPI · 2025Article
- Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis.Investigative ophthalmology & visual science · 2025Observational
- Altered Dynamic Functional Connectivity in High Myopia: Findings From Leading Eigenvector Dynamics Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- The neural signature of high myopia: structural and functional brain alterations and their cognitive-emotional associations.Frontiers in cell and developmental biology · 2025Review
- Analyzing the topological properties of resting-state brain function network connectivity based on graph theoretical methods in patients with high myopia.BMC ophthalmology · 2024Article
- Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Spontaneous changes in brain network centrality in patients with pathological myopia: A voxel-wise degree centrality analysis.CNS neuroscience & therapeutics · 2023Article
- Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopiaFrontiers in neuroscience · 2023Article
- Disrupted Topological Organization of Resting-State Functional Brain Networks in Age-Related Hearing Loss.Frontiers in aging neuroscience · 2022Article
- Altered Spontaneous Brain Activity Patterns of Meibomian Gland Dysfunction in Severely Obese Population Measured Using the Fractional Amplitude of Low-Frequency Fluctuations.Frontiers in psychiatry · 2022Article
- Cognitive dysfunctions in high myopia: An overview of potential neural morpho-functional mechanisms.Frontiers in neurology · 2022Review
- Exploration of abnormal dynamic spontaneous brain activity in patients with high myopiaFrontiers in human neuroscience · 2022Article
- Reorganized Brain Functional Network Topology in Presbycusis.Frontiers in aging neuroscience · 2022Article
- Meridional Anisotropy of Foveal and Peripheral Resolution Acuity in Adults With Emmetropia, Myopia, and Astigmatism.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High myopia (HM) is associated with impaired long-distance vision. accumulating evidences reported that abnormal visual experience leads to dysfunction in brain activity in HM even corrected. However, whether the long-term of abnormal visual experience lead to neuroanatomical changes remain unknown, the aim at this study is to investigate the alternation of cortical surface thickness in HM patients. 82 patients with HM (HM groups), 57 healthy controls (HC groups) were recruited. All participants underwent high-resolution T1 and resting-state functional magnetic resonance imaging (MRI) scans. The cortical thickness analysis was preformed to investigate the neuroanatomical changes in HM patients using computational anatomy toolbox (CAT 12) toolbox. Compare with HCs, HM patients showed decreased the cortical surface thickness in the left middle occipital gyrus (MOG), left inferior parietal lobule (IPL), right inferior temporal gyrus (ITG), right precuneus, right primary visual area 1 (V1), right superior temporal gyrus (STG), right superior parietal lobule (SPL), right occipital pole, and right the primary motor cortex (M1), and increased to the parietal operculum (OP4) (P < 0.01, FWE-corrected), the mean cortical thickness of right orbitofrontal cortex (OFC), right dorsolateral prefrontal cortex (DLPFC) and right subcallosal cortex showed negatively correlation between clinical variables (axis length (ALM), the average macular thickness (AMT), keratometer (KER) 1, KER2, the mean KER, the mean macular fovea thickness (MFK), the refractive diopter) in HM patients. Our result mainly provided an evidence of cortical thickness reduction and disconnection in visual center and visual processing area, and cortical thickness increase in left multimodal integration region in HM patients. This may provide important significance of the study of the neural mechanism of HM.
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