ArticleScientific reports2020
A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- The central cholinergic system as a therapeutic target in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Evolutionarily old brainstem neurons are required for the control of selective spatial attention.Nature communications · 2026Article
- Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Chilean brush-tailed mouse (Journal of neurophysiology · 2025Article
- GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response.Neuroscience bulletin · 2024Article
- Cross-modal enhancement of defensive behavior via parabigemino-collicular projections.Current biology : CB · 2024Article
- Retinal origin of orientation but not direction selective maps in the superior colliculus.Current biology : CB · 2024Article
- Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice.Frontiers in neural circuits · 2024Article
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Synaptic properties of mouse tecto-parabigeminal pathways.Frontiers in systems neuroscience · 2023Article
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- The parabigeminal nucleus is a source of "retinogeniculate replacement terminals" in mice that lack retinofugal input.The Journal of comparative neurology · 2022Article
- Structural connectivity of autonomic, pain, limbic, and sensory brainstem nuclei in living humans based on 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
- The organization of cholinergic projections in the visual thalamus of the mouse.The Journal of comparative neurology · 2022Article
- Donut-like organization of inhibition underlies categorical neural responses in the midbrain.Nature communications · 2022Article
- Nonlinear visuoauditory integration in the mouse superior colliculus.PLoS computational biology · 2021Article
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parabigeminal nucleus (PBG) is the mammalian homologue to the isthmic complex of other vertebrates. Optogenetic stimulation of the PBG induces freezing and escape in mice, a result thought to be caused by a PBG projection to the central nucleus of the amygdala. However, the isthmic complex, including the PBG, has been classically considered satellite nuclei of the Superior Colliculus (SC), which upon stimulation of its medial part also triggers fear and avoidance reactions. As the PBG-SC connectivity is not well characterized, we investigated whether the topology of the PBG projection to the SC could be related to the behavioral consequences of PBG stimulation. To that end, we performed immunohistochemistry, in situ hybridization and neural tracer injections in the SC and PBG in a diurnal rodent, the Octodon degus. We found that all PBG neurons expressed both glutamatergic and cholinergic markers and were distributed in clearly defined anterior (aPBG) and posterior (pPBG) subdivisions. The pPBG is connected reciprocally and topographically to the ipsilateral SC, whereas the aPBG receives afferent axons from the ipsilateral SC and projected exclusively to the contralateral SC. This contralateral projection forms a dense field of terminals that is restricted to the medial SC, in correspondence with the SC representation of the aerial binocular field which, we also found, in O. degus prompted escape reactions upon looming stimulation. Therefore, this specialized topography allows binocular interactions in the SC region controlling responses to aerial predators, suggesting a link between the mechanisms by which the SC and PBG produce defensive behaviors.
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