Evidence map›Paper›PMID 33004845›Full record

ArticleScientific reports2020

Influence of interapplicator distance on multibipolar radiofrequency ablation during physiological and interrupted liver perfusion in an in vivo porcine model.

F G M Poch, C A Neizert, B Geyer, O Gemeinhardt, L Bruder, S M Niehues, J L Vahldiek, K K Bressem, M E Kreis, K S Lehmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

F G M Poch *Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany. franz.poch@charite.de.
C A Neizert *Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany.
B GeyerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany.
O GemeinhardtCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of Radiology - Campus Benjamin Franklin, Berlin - Germany - Hindenburgdamm 30, 12203, Berlin, Germany.
L BruderCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany.
S M NiehuesCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of Radiology - Campus Benjamin Franklin, Berlin - Germany - Hindenburgdamm 30, 12203, Berlin, Germany.
J L VahldiekCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of Radiology - Campus Benjamin Franklin, Berlin - Germany - Hindenburgdamm 30, 12203, Berlin, Germany.
K K BressemCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of Radiology - Campus Benjamin Franklin, Berlin - Germany - Hindenburgdamm 30, 12203, Berlin, Germany.
M E KreisCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany.
K S LehmannCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Vascular Surgery - Campus Benjamin Franklin, Berlin - Hindenburgdamm 30, 12203, Berlin, Germany.
Freie Universität Berlin · DECharité - Universitätsmedizin Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiofrequency ablation (RFA) is a curative treatment option for early stage hepatocellular carcinoma (HCC). Vascular inflow occlusion to the liver (Pringle manoeuvre) and multibipolar RFA (mbRFA) represent possibilities to generate large ablations. This study evaluated the impact of different interapplicator distances and a Pringle manoeuvre on ablation area and geometry of mbRFA. 24 mbRFA were planned in porcine livers in vivo. Test series with continuous blood flow had an interapplicator distance of 20 mm and 15 mm, respectively. For a Pringle manoeuvre, interapplicator distance was predefined at 20 mm. After liver dissection, ablation area and geometry were analysed macroscopically and histologically. Confluent and homogenous ablations could be achieved with a Pringle manoeuvre and an interapplicator distance of 15 mm with sustained hepatic blood flow. Ablation geometry was inhomogeneous with an applicator distance of 20 mm with physiological liver perfusion. A Pringle manoeuvre led to a fourfold increase in ablation area in comparison to sustained hepatic blood flow (p < 0.001). Interapplicator distance affects ablation geometry of mbRFA. Strict adherence to the planned applicator distance is advisable under continuous blood flow. The application of a Pringle manoeuvre should be considered when compliance with the interapplicator distance cannot be guaranteed.

Indexed as

PerfusionAnimalsFemaleLiverModels, BiologicalPortal VeinRadiofrequency AblationRegional Blood FlowSwine

Identifiers

PMID33004845
PMCPMC7529885
OpenAlexW3090834025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.