Evidence map›Paper›PMID 33004805›Full record

ArticleScientific reports2020

Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques.

Simone Peli, Andrea Ronchi, Giada Bianchetti, Francesco Rossella, Claudio Giannetti, Marcella Chiari, Pasqualantonio Pingue, Francesco Banfi, Gabriele Ferrini

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simone PeliInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
Andrea RonchiInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
Giada BianchettiInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
Francesco RossellaNEST, Scuola Normale Superiore and CNR - Istituto Nanoscienze, piazza San Silvestro 12, 56127, Pisa, Italy.
Claudio GiannettiInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
Marcella ChiariIstituto di Chimica del Riconoscimento Molecolare, CNR, Milano, Italy.
Pasqualantonio PingueNEST, Scuola Normale Superiore and CNR - Istituto Nanoscienze, piazza San Silvestro 12, 56127, Pisa, Italy.
Francesco BanfiInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
Gabriele FerriniInterdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy. gabriele.ferrini@unicatt.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thermo-mechanical properties of streptavidin-conjugated gold nanospheres, adhered to a surface via complex molecular chains, are investigated by two-color infrared asynchronous optical sampling pump-probe spectroscopy. Nanospheres with different surface densities have been deposited and exposed to a plasma treatment to modify their polymer binding chains. The aim is to monitor their optical response in complex chemical environments that may be experienced in, e.g., photothermal therapy or drug delivery applications. By applying unsupervised learning techniques to the spectroscopic traces, we identify their thermo-mechanical response variation. This variation discriminates nanospheres in different chemical environments or different surface densities. Such discrimination is not evident based on a standard analysis of the spectroscopic traces. This kind of analysis is important, given the widespread application of conjugated gold nanospheres in medicine and biology.

Identifiers

PMID33004805
PMCPMC7530730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.