Trial reportNutrition & diabetes2020
Acute effects of whey protein on energy intake, appetite and gastric emptying in younger and older, obese men.
Trial report in Nutrition & diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Randomized Controlled Trial: Effects of a Bitter-Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects.Molecular nutrition & food research · 2025Trial
- The effects of collagen peptide supplementation on appetite and post-exercise energy intake in females: a randomised controlled trial.The British journal of nutrition · 2025Trial
- Short-term pre-meal whey protein microgel supplementation reduces postprandial glycemia and appetite in adults with overweight: An open-label randomised controlled trial.Obesity pillars · 2025Article
- Article
- Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms.Advances in nutrition (Bethesda, Md.) · 2023Review
- Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient.Endocrinology, diabetes & metabolism case reports · 2021Article
- Efficacy of Dietary and Supplementation Interventions for Individuals with Type 2 Diabetes.Nutrients · 2021Review
- Rational Use of Protein Supplements in the Elderly-Relevance of Gastrointestinal Mechanisms.Nutrients · 2021Review
- Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge.PLoS computational biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, older individuals. Obesity may be associated with diminished sensitivity to nutrients. We have reported that a 30-g whey protein drink slows gastric emptying more, and suppresses energy intake less, in older, than younger, non-obese men. The aim of this study was to determine the effect of a 30 g whey protein drink on energy intake, GE and glycaemia in obese, older and younger men.
methodsIn randomized, double-blind order, 10 younger (age: 27 ± 2 years; BMI: 36 ± 2 kg/m²), and 10 older (72 ± 1 years; 33 ± 1 kg/m²), obese men were studied twice. After an overnight fast, subjects ingested a test drink containing 30 g whey protein (120 kcal) or control (2 kcal). Postprandial gastric emptying (antral area, 2D Ultrasound) and blood glucose concentrations were measured for 180 min. At t = 180 min subjects were given a buffet meal and ad libitum energy intake was assessed.
resultsOlder subjects ate non-significantly less (~20%) that the younger subjects (effect of age, P = 0.16). Whey protein had no effect on subsequent energy intake (kcal) compared to control in either the younger (decrease 3 ± 8%) or older (decrease 2 ± 8%) obese men (age effect P > 0.05, protein effect P = 0.46, age × protein interaction effect P = 0.84). Whey protein slowed gastric emptying, to a similar degree in both age groups (50% emptying time: control vs. protein young men: 255 ± 5 min vs. 40 ± 7 min; older men: 16 ± 5 min vs. 50 ± 8 min; protein effect P = 0.001, age effect P = 0.93, age × protein interaction effect P = 0.13).
conclusionsOur data suggest that obesity may blunt/abolish the age-related effect of whey protein on suppression of energy intake.
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