ArticleNature communications2020
Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Vitamins DFrontiers in immunology · 2022Trial
- Beyond bacilli: integrating the microbiome into the TB research agenda.Gut microbes · 2026Review
- Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.Nature communications · 2026Article
- Large-scale analysis of temporal gene expression variation in peripheral blood.Nature communications · 2026Article
- Global trends in human birth and death seasonality reveal climate-related shifts in reproductive timing.bioRxiv : the preprint server for biology · 2026Article
- Genetic and non-genetic factors distinctly shape the variation of the immune response in cattle.Nature communications · 2026Article
- DiDyNet: a robust framework for differential dynamic network inference from longitudinal multi-omics data.Bioinformatics advances · 2026Article
- A multi-omics machine learning classifier for outgrowth of cow's milk allergy in children.Molecular omics · 2025Article
- Tapping natures rhythm: the role of season in mitochondrial function and genetics in the UK biobank.Human genomics · 2025Article
- Circadian Regulation of Vitamin D Target Genes Reveals a Network Shaped by Individual Responsiveness.Nutrients · 2025Article
- Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health.npj metabolic health and disease · 2025Article
- Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.Scientific reports · 2024Article
- A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.Nature communications · 2024Article
- Human immune and metabolic biomarker levels, and stress-biomarker associations, differ by season: Implications for biomedical health research.Brain, behavior, & immunity - health · 2024Article
- Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure.Molecular omics · 2024Review
- Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease.Cell host & microbe · 2024Article
- An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.Nature communications · 2024Article
- From 'Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators.Current atherosclerosis reports · 2023Review
- Exploring human biology with N-of-1 clinical trials.Cambridge prisms. Precision medicine · 2023Article
- Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The influence of seasons on biological processes is poorly understood. In order to identify biological seasonal patterns based on diverse molecular data, rather than calendar dates, we performed a deep longitudinal multiomics profiling of 105 individuals over 4 years. Here, we report more than 1000 seasonal variations in omics analytes and clinical measures. The different molecules group into two major seasonal patterns which correlate with peaks in late spring and late fall/early winter in California. The two patterns are enriched for molecules involved in human biological processes such as inflammation, immunity, cardiovascular health, as well as neurological and psychiatric conditions. Lastly, we identify molecules and microbes that demonstrate different seasonal patterns in insulin sensitive and insulin resistant individuals. The results of our study have important implications in healthcare and highlight the value of considering seasonality when assessing population wide health risk and management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.