Evidence map›Paper›PMID 33004605›Full record

ArticleNeurology2020

Co-occurrence of apathy and impulse control disorders in Parkinson disease.

Bonnie M Scott, Robert S Eisinger, Matthew R Burns, Janine Lopes, Michael S Okun, Aysegul Gunduz, Dawn Bowers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
  2. Article
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  5. Article
  6. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  7. Article
  8. Co-Occurrence of Apathy and Impulse Control Disorders in Parkinson Disease: Variation across Multiple Measures.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
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  15. Review
  16. Article
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  18. Article
  19. Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bonnie M ScottFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville. bonnie.m.scott@phhp.ufl.edu.ORCID 0000-0002-4868-6238
Robert S EisingerFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Matthew R BurnsFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Janine LopesFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Michael S OkunFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Aysegul GunduzFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Dawn BowersFrom the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Local field potentials reveal reward processing and impulse control disorders in Parkinson’s diseaseF30NS111841 · NINDS · UNIVERSITY OF FLORIDA · PI EISINGER, ROBERT STEPHEN · 2019 to 2022
$124k
NCATS NIH HHS KL2 TR001429NCATS NIH HHS TL1 TR001428NCATS NIH HHS UL1 TR001427NINDS NIH HHS F30 NS111841NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

objectiveTo empirically test whether apathy and impulse control disorders (ICDs) represent independent, opposite ends of a motivational spectrum.

methodsIn this single-center, cross-sectional study, we obtained retrospective demographics and clinical data for 887 patients with idiopathic Parkinson disease (PD) seen at a tertiary care center. Mood and motivation disturbances were classified using recommended cutoff scores from self-reported measures of apathy, ICD, anxiety, and depression.

resultsPrevalence rates included 29.0% of patients with PD with depression, 40.7% with anxiety, 41.3% with apathy, 27.6% with ICDs, and 17.0% with both apathy and ICD. The majority (61.6%) of people reporting clinically significant ICDs also reported clinically significant apathy, and more than a third of patients with apathy (41.3%) also reported elevated ICD. Anxiety and depression were highest in patients with both apathy and ≥1 ICDs. Dopamine agonist use was higher in people with only ICD compared to people with only apathy. Mood significantly interacted with demographic variables to predict motivational disturbances.

conclusionsMotivational disturbances are common comorbid conditions in patients with PD. In addition, these complex behavioral syndromes interact with mood in clinically important ways that may influence the design of future clinical trials and the development of novel therapies. This study challenges the concept of apathy and ICD in PD as opposite ends of a spectrum.

Indexed as

AnxietyDepressionDisruptive, Impulse Control, and Conduct DisordersParkinson DiseaseAgedApathyCross-Sectional StudiesFemaleHumansMaleMiddle AgedMotivationRetrospective Studies

Identifiers

PMID33004605
PMCPMC7734726
OpenAlexW3089983259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.