Evidence map›Paper›PMID 33004514›Full record

ArticleScience (New York, N.Y.)2020

Extensive heterogeneity in somatic mutation and selection in the human bladder.

Andrew R J Lawson, Federico Abascal, Tim H H Coorens, Yvette Hooks, Laura O'Neill, Calli Latimer, Keiran Raine, Mathijs A Sanders, Anne Y Warren, Krishnaa T A Mahbubani and 22 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026
    Review
  18. Review
  19. Article
  20. Review

132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Andrew R J LawsonCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0003-3592-1005
Federico AbascalCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-6201-1587
Tim H H CoorensCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-5826-3554
Yvette HooksCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Laura O'NeillCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Calli LatimerCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Keiran RaineCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-5634-1539
Mathijs A SandersCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-8575-9213
Anne Y WarrenDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1170-7867
Krishnaa T A MahbubaniDepartment of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1327-2334
Bethany BarehamDepartment of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-1892-8256
Timothy M ButlerCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0001-5803-1035
Luke M R HarveyCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0001-8111-1885
Alex CaganCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-7857-4771
Andrew MenziesCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Luiza MooreCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0001-5315-516X
Alexandra J ColquhounDepartment of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
William TurnerDepartment of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Benjamin ThomasThe Royal Melbourne Hospital, Parkville, Victoria 3010, Australia.ORCID 0000-0002-1330-122X
Vincent GnanapragasamAcademic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.
Nicholas WilliamsCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0003-3989-9167
Doris M RasslDepartment of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0AY, UK.
Harald VöhringerEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK.ORCID 0000-0003-2513-4518
Sonia ZumalaveMobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.ORCID 0000-0002-2108-1861
Jyoti NangaliaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
José M C TubíoMobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.ORCID 0000-0003-3540-2459
Moritz GerstungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK.ORCID 0000-0001-6709-963X
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-0633-3696
Michael R StrattonCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0001-6035-153X
Peter J CampbellCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-3921-0510
Thomas J MitchellCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.ORCID 0000-0003-0761-9503
Iñigo MartincorenaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK. im3@sanger.ac.uk.ORCID 0000-0003-1122-4416

Funding

Cancer Research UK 21777Cancer Research UK 23917Cancer Research UK 27176Wellcome Trust
6 · The paper itself

Abstract

The extent of somatic mutation and clonal selection in the human bladder remains unknown. We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (

Indexed as

Genes, NeoplasmMutagenesisSelection, GeneticAdultAgedAPOBEC DeaminasesBiopsyChromatin Assembly and DisassemblyFemaleHumansMaleMiddle AgedMutagensMutationUrinary BladderUrinary Bladder NeoplasmsAPOBEC DeaminasesMutagens

Identifiers

PMID33004514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.