Observational studyJournal of the American Society of Nephrology : JASN2020
Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Observational study in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function.Communications biology · 2023Pooled it
- Effect of exercise interventions for sleep quality in patients with chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2023Pooled it
- Relationship between modifiable lifestyle factors and chronic kidney disease: a bibliometric analysis of top-cited publications from 2011 to 2020.BMC nephrology · 2022Pooled it
- Sleep Duration/Quality With Health Outcomes: An Umbrella Review of Meta-Analyses of Prospective Studies.Frontiers in medicine · 2021Pooled it
- The prevalence and associations of stroke history with self-reported sleep disturbances in China: a nationwide cross-sectional study.BMC public health · 2026Article
- Associations of afternoon naps with progression of advanced cardiovascular-kidney-metabolic syndrome among Chinese adults aged 45 years and above.Scientific reports · 2025Article
- Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study.Renal failure · 2025Article
- Long nighttime sleep duration and risk of renal tubular damage: evidence from rural China and a Mendelian randomization analysis.Renal failure · 2025Observational
- The impact of sleep duration on the incidence of new-onset chronic kidney disease in community-dwelling adults: a nationwide cohort study.Annals of medicine · 2025Article
- Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation.Global medical genetics · 2025Article
- Association between weekend catch-up sleep and chronic kidney disease: insights from NHANES 2017-2020.Renal failure · 2025Article
- Association between sleep duration and CVD mortality: a prospective cohort study based on middle-aged and elderly chest pain patients.BMC cardiovascular disorders · 2025Article
- Weekend catch-up sleep is associated with a decreased risk of kidney disease in American adults: an analysis of NHANES 2017-2020.International urology and nephrology · 2025Article
- UK Biobank study of the association between circadian syndrome and cardio-kidney events or all-cause mortality.Communications medicine · 2025Article
- Life's Essential 8 scores, socioeconomic deprivation, genetic susceptibility, and new-onset chronic kidney diseases.Chinese medical journal · 2025Article
- Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Relationship between weekend catch-up sleep and the risk of diabetic kidney disease.Archives of endocrinology and metabolism · 2025Article
- Causal Associations of Obstructive Sleep Apnea With Cancer Risk: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome.Journal of the American Heart Association · 2025Article
- Associations of Dietary Zinc Supplementation and Sleep Patterns with Chronic Kidney Disease Risk: A Prospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies have found sleeping behaviors, such as sleep duration, to be associated with kidney function and cardiovascular disease risk. However, whether short or long sleep duration is a causative factor for kidney function impairment has been rarely studied.
methodsWe studied data from participants aged 40-69 years in the UK Biobank prospective cohort, including 25,605 self-reporting short-duration sleep (<6 hours per 24 hours), 404,550 reporting intermediate-duration sleep (6-8 hours), and 35,659 reporting long-duration sleep (≥9 hours) in the clinical analysis. Using logistic regression analysis, we investigated the observational association between the sleep duration group and prevalent CKD stages 3-5, analyzed by logistic regression analysis. We performed Mendelian randomization (MR) analysis involving 321,260 White British individuals using genetic instruments (genetic variants linked with short- or long-duration sleep behavior as instrumental variables). We performed genetic risk score analysis as a one-sample MR and extended the finding with a two-sample MR analysis with CKD outcome information from the independent CKDGen Consortium genome-wide association study meta-analysis.
resultsShort or long sleep duration clinically associated with higher prevalence of CKD compared with intermediate duration. The genetic risk score for short (but not long) sleep was significantly related to CKD (per unit reflecting a two-fold increase in the odds of the phenotype; adjusted odds ratio, 1.80; 95% confidence interval, 1.25 to 2.60). Two-sample MR analysis demonstrated causal effects of short sleep duration on CKD by the inverse variance weighted method, supported by causal estimates from MR-Egger regression.
conclusionsThese findings support an adverse effect of a short sleep duration on kidney function. Clinicians may encourage patients to avoid short-duration sleeping behavior to reduce CKD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.