Evidence map›Paper›PMID 33004417›Full record

ArticleeNeuro

Induction of Short-Term Sensitization by an Aversive Chemical Stimulus in Zebrafish Larvae.

Adam C Roberts, Joseph B Alzagatiti, Duy T Ly, Julia M Chornak, Yuqi Ma, Asif Razee, Gohar Zavradyan, Umair Khan, Julia Lewis, Aishwarya Natarajan and 25 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Advancing Zebrafish (Veterinary sciences · 2025
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 7 institutions in 2 countries.

Adam C RobertsDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Joseph B AlzagatitiDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Duy T LyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Julia M ChornakDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095.
Yuqi MaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Asif RazeeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Gohar ZavradyanDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Umair KhanDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095.
Julia LewisDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095.
Aishwarya NatarajanDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095.
Alisher BaibussinovDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Jasmine EmtageDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095.
Meghna KomaranchathDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095.
Jared RichardsDepartment of Psychology, Rowan University, Glassboro, NJ 08028.
Michelle HoangDepartment of Biology, Brown University, Providence, RI 02912.
Jason AlipioDepartment of Psychology, California State University at San Bernardino, San Bernardino, CA 92407.
Emma LaurentSchool of Biology, University of St. Andrews, St. Andrews, Fife, Scotland, UK.
Amit KumarDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
C S CampbellDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Rebecca StarkDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095.
Javier CarmonaDepartment of Physics, University of California, Los Angeles, Los Angeles, CA 90095.
Anjum HussainDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Courtney ScaramellaDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Jenan HusainDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Reed BuckDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095.
Ava JafarpourDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Miguel GarciaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Steve MendozaDepartment of Physics, University of California, Los Angeles, Los Angeles, CA 90095.
Gerardo SandovalDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Brandon AgundezDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Amanda FinkDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Emily DeutschDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.ORCID 0000-0003-0143-8525
Sarah C HernandezDepartment of Psychology, California State University at Fullerton, Fullerton, CA 92831.
Katsushi ArisakaDepartment of Physics, University of California, Los Angeles, Los Angeles, CA 90095.
David L GlanzmanDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095 glanzman@ucla.edu.
University of California, Los Angeles · USCalifornia State University, Fullerton · USAllen Institute for Brain Science · USCalifornia State University, San Bernardino · USJohn Brown University · USRowan University · USUniversity of St Andrews · GB

Funding

PLASTICITY AT SENSORIMOTOR SYNAPSES IN CULTURER01NS029563 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GLANZMAN, DAVID L · 1992 to 2017
$2.6M
NINDS NIH HHS R01 NS029563
6 · The paper itself

Abstract

Larval zebrafish possess a number of molecular and genetic advantages for rigorous biological analyses of learning and memory. These advantages have motivated the search for novel forms of memory in these animals that can be exploited for understanding the cellular and molecular bases of vertebrate memory formation and consolidation. Here, we report a new form of behavioral sensitization in zebrafish larvae that is elicited by an aversive chemical stimulus [allyl isothiocyanate (AITC)] and that persists for ≥30 min. This form of sensitization is expressed as enhanced locomotion and thigmotaxis, as well as elevated heart rate. To characterize the neural basis of this nonassociative memory, we used transgenic zebrafish expressing the fluorescent calcium indicator GCaMP6 (Chen et al., 2013); because of the transparency of larval zebrafish, we could optically monitor neural activity in the brain of intact transgenic zebrafish before and after the induction of sensitization. We found a distinct brain area, previously linked to locomotion, that exhibited persistently enhanced neural activity following washout of AITC; this enhanced neural activity correlated with the behavioral sensitization. These results establish a novel form of memory in larval zebrafish and begin to unravel the neural basis of this memory.

Indexed as

MemoryZebrafishAnimalsAnimals, Genetically ModifiedLarvaLocomotionbehavioral plasticitylearningmemorysensitizationzebrafish

Identifiers

PMID33004417
PMCPMC7729299
OpenAlexW3090277901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.