Evidence map›Paper›PMID 33004258›Full record

ReviewTrends in microbiology2021

These Are the Genes You're Looking For: Finding Host Resistance Genes.

Jeffrey S Bourgeois, Clare M Smith, Dennis C Ko

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeffrey S BourgeoisDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA; University Program in Genetics and Genomics, Duke University, Durham, NC, USA.
Clare M SmithDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA; University Program in Genetics and Genomics, Duke University, Durham, NC, USA; Duke Human Vaccine Institute, School of Medicine, Duke University Durham, NC, USA.
Dennis C KoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA; University Program in Genetics and Genomics, Duke University, Durham, NC, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC, USA. Electronic address: dennis.ko@duke.edu.

Funding

Serologic Biomarkers of Human Sexually Transmitted Infection and DiseaseU19AI084044 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAVEL, JACQUES · 2009 to 2018
$22.8M
HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITYR01AI118903 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2015 to 2024
$4.2M
AN ATLAS OF SHARED GENETIC ARCHITECTURE CONNECTING CELL BIOLOGY AND HUMAN DISEASER21AI133305 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE, WANG, LIUYANG · 2018 to 2019
$440k
SALMONELLA HIJACKING OF STAT3 AND CONSEQUENCES FOR DISEASER21AI146520 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2019 to 2020
$428k
Regulation of Salmonella virulence by interspecies methylthioadenosine signalingR21AI144586 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2019 to 2020
$428k
Mechanisms of methylthioadenosine signaling during Salmonella infectionF31AI143147 · NIAID · DUKE UNIVERSITY · PI BOURGEOIS, JEFFREY · 2019 to 2021
$105k
NIAID NIH HHS F31 AI143147NIAID NIH HHS R01 AI118903NIAID NIH HHS R21 AI133305NIAID NIH HHS R21 AI144586NIAID NIH HHS R21 AI146520NIAID NIH HHS U19 AI084044
6 · The paper itself

Abstract

Humanity's ongoing struggle with new, re-emerging and endemic infectious diseases serves as a frequent reminder of the need to understand host-pathogen interactions. Recent advances in genomics have dramatically advanced our understanding of how genetics contributes to host resistance or susceptibility to bacterial infection. Here we discuss current trends in defining host-bacterial interactions at the genome-wide level, including screens that harness CRISPR/Cas9 genome editing, natural genetic variation, proteomics, and transcriptomics. We report on the merits, limitations, and findings of these innovative screens and discuss their complementary nature. Finally, we speculate on future innovation as we continue to progress through the postgenomic era and towards deeper mechanistic insight and clinical applications.

Indexed as

GenomicsAnimalsBacteriaCRISPR-Cas SystemsGene EditingHigh-Throughput Nucleotide SequencingHost-Pathogen InteractionsHumansMicebacteriacollaborative crossdual RNA-seqeQTLgenetic resistanceGWAS

Identifiers

PMID33004258
PMCPMC7969353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.