ArticleBMC medicine2020
Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study : Maternal lipid profile in early pregnancy and foetal growth.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Association of triglyceride-glucose index and triglyceride-to-HDL cholesterol ratio with pregnancy-related risks: a meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Trimester-Specific Serum Lipid Profiles in Gestational Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Association between maternal lipid levels during pregnancy and delivery of small for gestational age: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Association of Maternal Overweight/Obesity Metabolic Phenotypes With Longitudinal Foetal Anthropometric Measurements.Diabetes, obesity & metabolism · 2026Article
- Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose.Journal of diabetes investigation · 2026Article
- Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling.Nature communications · 2026Article
- Second trimester serum lipidomics predicts large-for-gestational-age infants in apparently metabolically healthy pregnancies.iScience · 2026Article
- Cardiac Implications of Preeclampsia: A Review.Journal of personalized medicine · 2026Review
- Lipid profile analysis during pregnancy and its association with adverse pregnancy outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Advanced Maternal Age and Risk of Large-for-Gestational-Age Infants: Mediating Roles of Prenatal Body Mass Index and Specific Lipid Profiles.International journal of women's health · 2026Article
- Cardiometabolic Markers Associated With Altered Fetal Growth in Mediterranean Cohort.Maternal & child nutrition · 2025Article
- Correlation between the first-trimester non-traditional lipid parameters with the risk of gestational diabetes mellitus in pregnancy.BMC endocrine disorders · 2025Article
- Perinatal Shifts in Fecal-Derived Metabolites and Associations with Postpartum Depression.bioRxiv : the preprint server for biology · 2025Article
- Predictive ability of lipid indices for large-for-gestational-age infants in pregnant females with gestational diabetes mellitus.World journal of diabetes · 2025Article
- Article
- Observational
- Changes in Lipid Profiles with the Progression of Pregnancy in Black Women.Journal of clinical medicine · 2024Article
- Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth.Journal of diabetes investigation · 2024Article
- Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome.Journal of lipids · 2024Review
- Association between maternal lipid profiles and vitamin D status in second trimester and risk of LGA or SGA: a retrospective study.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipids such as cholesterol and triglycerides play an important role in both maternal and foetal energy metabolism. Little is known about maternal lipid levels in pregnancy and their effect on foetal growth. The aim of this study was to assess maternal lipid levels, foetal growth and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA).
methodsWe included 5702 women from the Generation R Study, a prospective population-based cohort. Maternal lipid levels (total cholesterol, triglycerides and high-density lipoprotein cholesterol [HDL-c]) were measured in early pregnancy (median 13.4 weeks, 90% range [10.5 to 17.2]). Low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated. Foetal growth was measured repeatedly by ultrasound. Information on birth anthropometrics was retrieved from medical records. A birth weight below the 10th percentile was defined as SGA and above the 90th percentile as LGA.
resultsMaternal triglyceride and remnant cholesterol levels were associated with increased foetal head circumference and abdominal circumference growth rates. Triglycerides and remnant cholesterol were positively associated with the risk of LGA (odds ratio [OR] 1.11, 95% confidence interval [CI] [1.01 to 1.22] and OR 1.11, 95% CI [1.01 to 1.23], respectively). These associations were independent of maternal pre-pregnancy body mass index, but not maternal glucose levels. We observed no association between maternal lipids in early pregnancy and SGA.
conclusionsOur study suggests a novel association of early pregnancy triglyceride and remnant cholesterol levels with foetal growth, patterns of foetal growth and the risk of LGA. Future studies are warranted to explore clinical implication possibilities.
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