Evidence map›Paper›PMID 33004014›Full record

ArticleBMC genetics2020

Meta-analyses of genome wide association studies in lines of laying hens divergently selected for feather pecking using imputed sequence level genotypes.

Clemens Falker-Gieske, Hanna Iffland, Siegfried Preuß, Werner Bessei, Cord Drögemüller, Jörn Bennewitz, Jens Tetens

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Relationships between Damaging Behaviours and Health in Laying Hens.Animals : an open access journal from MDPI · 2022
    Review
  8. The Impact of ProbioticAnimals : an open access journal from MDPI · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Clemens Falker-GieskeDepartment of Animal Sciences, Georg-August-University, Burckhardtweg 2, 37077, Göttingen, Germany. clemens.falker-gieske@uni-goettingen.de.ORCID 0000-0001-9160-1909
Hanna IfflandInstitute of Animal Science, University of Hohenheim, Garbenstr. 17, 70599, Stuttgart, Germany.
Siegfried PreußInstitute of Animal Science, University of Hohenheim, Garbenstr. 17, 70599, Stuttgart, Germany.
Werner BesseiInstitute of Animal Science, University of Hohenheim, Garbenstr. 17, 70599, Stuttgart, Germany.
Cord DrögemüllerInstitute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstr. 109a, 3001, Bern, Switzerland.
Jörn BennewitzInstitute of Animal Science, University of Hohenheim, Garbenstr. 17, 70599, Stuttgart, Germany.
Jens TetensDepartment of Animal Sciences, Georg-August-University, Burckhardtweg 2, 37077, Göttingen, Germany.
University of Hohenheim · DEUniversity of Göttingen · DEUniversity of Bern · CH

Funding

Deutsche Forschungsgemeinschaft BE3703/8-2Deutsche Forschungsgemeinschaft TE622/4-2
6 · The paper itself

Abstract

backgroundFeather pecking (FP) is damaging behavior in laying hens leading to global economic losses in the layer industry and massive impairments of animal welfare. The objective of the study was to discover genetic variants and affected genes that lead to FP behavior. To achieve that we imputed low-density genotypes from two different populations of layers divergently selected for FP to sequence level by performing whole genome sequencing on founder and half-sib individuals. In order to decipher the genetic structure of FP, genome wide association studies and meta-analyses of two resource populations were carried out by focusing on the traits 'feather pecks delivered' (FPD) and the 'posterior probability of a hen to belong to the extreme feather pecking subgroup' (pEFP).

resultsIn this meta-analysis, we discovered numerous genes that are affected by polymorphisms significantly associated with the trait FPD. Among them SPATS2L, ZEB2, KCHN8, and MRPL13 which have been previously connected to psychiatric disorders with the latter two being responsive to nicotine treatment. Gene set enrichment analysis revealed that phosphatidylinositol signaling is affected by genes identified in the GWAS and that the Golgi apparatus as well as brain structure may be involved in the development of a FP phenotype. Further, we were able to validate a previously discovered QTL for the trait pEFP on GGA1, which contains variants affecting NIPA1, KIAA1211L, AFF3, and TSGA10.

conclusionsWe provide evidence for the involvement of numerous genes in the propensity to exhibit FP behavior that could aid in the selection against this unwanted trait. Furthermore, we identified variants that are involved in phosphatidylinositol signaling, Golgi metabolism and cell structure and therefore propose changes in brain structure to be an influential factor in FP, as already described in human neuropsychiatric disorders.

Indexed as

Behavior, AnimalFeathersAnimalsChickensFemaleGenetic Association StudiesGenotypeHaplotypesPhenotypePolymorphism, Single NucleotideQuantitative Trait LociChickenFeather peckingGenome wide association studyImputationMeta-analysisWhole genome sequencing

Identifiers

PMID33004014
PMCPMC7528462
OpenAlexW3090607849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.