ArticleBiointerphases2020
DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.
Article in Biointerphases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Where Have You Been? Backtracking Microplastic to Its Source Using the Biomolecular Composition of the Ecocorona.Environmental science & technology · 2025Article
- DNA coronas resist nuclease degradation.Biophysical journal · 2025Article
- Proteome Alterations and Nucleosome Activation in Rat Myoblasts Treated with Cerium Oxide Nanoparticles.ACS omega · 2024Article
- DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with implications for autoimmune diseases.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Protocols for isolation and characterization of nanoparticle biomolecular corona complexes.Frontiers in toxicology · 2024Article
- Cell and biomaterial delivery strategies to induce immune tolerance.Advanced drug delivery reviews · 2023Review
- Silver nanoparticle interactions with glycated and non-glycated human serum albumin mediate toxicity.Frontiers in toxicology · 2023Article
- Understanding the Significance of Sample Preparation in Studies of the Nanoparticle Metabolite Corona.ACS measurement science au · 2022Article
- The Interaction of Anti-DNA Antibodies with DNA: Evidence for Unconventional Binding Mechanisms.International journal of molecular sciences · 2022Review
- Cascade Filtration With PCR Detection and Field-Flow-Fractionation Online With ICP-MS for the Characterization of DNA Interaction With Suspended Particulate Matter.Frontiers in chemistry · 2022Article
- Environmental dimensions of the protein corona.Nature nanotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
There has been much recent interest in the protein "corona," the nonspecific adsorption of proteins on the surface of nanoparticles used in biological applications. This research investigates an analogous DNA corona. We find that particles (200 nm and 1 μm) incubated with DNA form a DNA corona, with a higher concentration of DNA adsorbed on the surface of cationic nanoparticles. With protein present, a combined DNA and protein corona is formed although DNA in solution displaces protein from the nanoparticle surface. Displacement of protein from the nanoparticle surface is dependent on the concentration of DNA in solution and was also observed for planar surfaces. Overall, we expect this investigation of the DNA corona to be important for nanomedicine applications, as well as disease states, especially systemic lupus erythematosus, in which biological particles with bound DNA are important mediators of inflammation and thrombosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.