Evidence map›Paper›PMID 33003681›Full record

Observational studyRhode Island medical journal (2013)2020

Concurrent Utilization of Prescription Opioids and Non-opioid Controlled Substances: Rhode Island Prescription Drug Monitoring Program, 2018.

Eric P Borrelli, Blake Morphis, Rouba Youssef, Laura C Chambers, Benjamin D Hallowell, Jeffrey Bratberg, Stephen J Kogut

Abstract readObservational Study
PubMed
In one paragraph

Observational study in Rhode Island medical journal (2013), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eric P BorrelliPhD Candidate in Pharmaceutical Sciences, Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island.
Blake MorphisDirector of Analytic Services, Healthcentric Advisors.
Rouba YoussefHealth Information Analyst, Healthcentric Advisors. (during time of study).
Laura C ChambersEpidemiologist, Rhode Island Department of Health.
Benjamin D HallowellBiostatistician, Rhode Island Department of Health.
Jeffrey BratbergClinical Professor, Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island.
Stephen J KogutProfessor of Pharmacy Practice; Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island.
American Association of Colleges of Pharmacy · USHealthcentric Advisors · USRhode Island Department of Health · US

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI Brandon David Lewis Marshall · 2018 to 2026
$23.4M
6 · The paper itself

Abstract

objectiveTo estimate the prevalence of concurrent prescription opioid and non-opioid controlled substance use in Rhode Island (RI).

methodsWe conducted a cross sectional observational study using data from the RI Prescription Drug Monitoring Program on controlled substance prescriptions dispensed in 2018. We estimated the prevalence of concurrent use of other prescribed controlled substances among adults who received at least one opioid prescription.

resultsIn 2018, 142,692 RI adult residents received at least one opioid prescription, of whom 25.1% (99% confidence interval [CI]: 24.8-25.4) were concurrently prescribed at least one other controlled substance, including benzodiazepines (17.0%, 99% CI: 16.8-17.3), medications for insomnia (4.0%, 99% CI: 3.9-4.2), and stimulants (3.8%, 99% CI: 3.6-3.9).

conclusionThe concurrent use of prescription opioids and other prescribed controlled substances is common. Our findings suggest an urgent need to implement focused initiatives to address controlled substance polypharmacy to reduce the risk of overdose.

Indexed as

Analgesics, OpioidDrug OverdosePrescription Drug Monitoring ProgramsAdultAgedControlled SubstancesCross-Sectional StudiesFemaleHumansMaleMedicarePrescriptionsRhode IslandUnited StatesAnalgesics, OpioidControlled Substancesbenzodiazepinescontrolled substanceopioidsstimulantsZ-drugs

Identifiers

PMID33003681
OpenAlexW3089899213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.