Evidence map›Paper›PMID 33003647›Full record

ArticleInternational journal of molecular sciences2020

The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and

Sabina L Ray, David J Coulson, Megan Li Yuen Yeoh, Alice Tamara, Jevi Septyani Latief, Sherin Bakhashab, Jolanta U Weaver

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. Endothelial Dysfunction in Diabetes Mellitus: New Insights.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
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  19. Article
  20. LncRNA HOXA11-AS Promotes Myocardial Injury in Chronic Heart Failure by Sponging miR-342-3p.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sabina L RayTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.
David J CoulsonTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.
Megan Li Yuen YeohTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.ORCID 0000-0003-4579-8282
Alice TamaraTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.
Jevi Septyani LatiefTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.
Sherin BakhashabTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.ORCID 0000-0003-1580-0409
Jolanta U WeaverTranslational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.
Newcastle University · GBKing Abdulaziz University · SAQueen Elizabeth Hospital · GB

Funding

Diabetes Research and Wellness Foundation UK Open funding 2011Diabetes Research Fund at Queen Elizabeth Hospital, Gateshead, UK None
6 · The paper itself

Abstract

Cardiovascular disease (CVD) correlates with inflammation and a reduction in circulating endothelial progenitor cells (cEPCs). Recently, CVD was shown to be the main cause of mortality in individuals with type 1 diabetes (T1DM). In animals, miR-342 was shown to exert an anti-inflammatory effect in CVD. Hypothesis: miR-342-3p/-5p are downregulated in subclinical CVD (T1DM), whereas inflammatory cytokines are upregulated. We studied miR -342 -3p/5p in plasma/peripheral blood mononuclear cells (PBMCs) in 29 T1DM and 20 controls (HC). Vascular health was measured by fibronectin adhesion assay (FAA), cEPCs (CD45

Indexed as

AdultBlood VesselsCardiovascular DiseasesConnexinsCytokinesDiabetes Mellitus, Type 1FemaleHumansInflammationLeukocytes, MononuclearMaleMicroRNAsMiddle AgedConnexinsCytokinesMicroRNAsMIRN342 microRNA, humanPANX2 protein, humanCVDCXCR1/2inflammationmiR-342-3p/-5pPANX2T1DMtherapeutic targetsTIMP-1TNF-α

Identifiers

PMID33003647
PMCPMC7582278
OpenAlexW3090356208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.