Evidence map›Paper›PMID 33003586›Full record

ArticleInternational journal of molecular sciences2020

Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature.

Theophilos Tzaridis, Katrin S Reiners, Johannes Weller, Daniel Bachurski, Niklas Schäfer, Christina Schaub, Michael Hallek, Björn Scheffler, Martin Glas, Ulrich Herrlinger and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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  18. Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Theophilos TzaridisInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany.
Katrin S ReinersInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-5908-8823
Johannes WellerDivision of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Bonn, University Hospital Bonn, 53127 Bonn, Germany.
Daniel BachurskiDepartment I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Cologne, CECAD Center of Excellence on ''Cellular Stress Responses in Aging-Associated Diseases'', Center for Molecular Medicine Cologne, University of Cologne, 50937Cologne, Germany.ORCID 0000-0001-9168-9680
Niklas SchäferDivision of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Bonn, University Hospital Bonn, 53127 Bonn, Germany.
Christina SchaubDivision of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Bonn, University Hospital Bonn, 53127 Bonn, Germany.
Michael HallekDepartment I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Cologne, CECAD Center of Excellence on ''Cellular Stress Responses in Aging-Associated Diseases'', Center for Molecular Medicine Cologne, University of Cologne, 50937Cologne, Germany.
Björn SchefflerDKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), German Cancer Consortium (DKTK), DKFZ Heidelberg & Partner Site Univ Hospital Essen, 45147 Essen, Germany.
Martin GlasDivision of Clinical Neurooncology, Department of Neurology and West German Cancer Center (WTZ), German Cancer Consortium, University Hospital Essen, 45147 Essen, Germany.
Ulrich HerrlingerDivision of Clinical Neurooncology, Department of Neurology, Center of Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf, Partner Site Bonn, University Hospital Bonn, 53127 Bonn, Germany.
Stefan WildMiltenyi Biotec & Biomedicine GmbH, 51429 Bergisch Gladbach, Germany.
Christoph CochInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany.
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany.
University Hospital Bonn · DEUniversity of Bonn · DEUniversity of Cologne · DEDeutschen Konsortium für Translationale Krebsforschung · DEGerman Cancer Research Center · DEMiltenyi Biotec (Germany) · DE

Funding

Deutsche Forschungsgemeinschaft EXC2151-390873048Rheinische Friedrich-Wilhelms-Universität Bonn O-129.0106
6 · The paper itself

Abstract

Glioblastoma is a devastating disease, for which biomarkers allowing a prediction of prognosis are urgently needed. microRNAs have been described as potentially valuable biomarkers in cancer. Here, we studied a panel of microRNAs in extracellular vesicles (EVs) from the serum of glioblastoma patients and evaluated their correlation with the prognosis of these patients. The levels of 15 microRNAs in EVs that were separated by size-exclusion chromatography were studied by quantitative real-time PCR, followed by CD44 immunoprecipitation (SEC + CD44), and compared with those from the total serum of glioblastoma patients (

Indexed as

AdultAgedBiomarkers, TumorDisease-Free SurvivalExtracellular VesiclesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGlioblastomaHumansHyaluronan ReceptorsMaleMicroRNAsMiddle AgedPrognosisYoung AdultBiomarkers, TumorHyaluronan ReceptorsMicroRNAsbiomarkersCD44extracellular vesiclesglioblastomaimmunoprecipitationmicroRNA

Identifiers

PMID33003586
PMCPMC7583802
OpenAlexW3091505332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.