ArticleMarine drugs2020
LC-MS/MS Method Development for the Discovery and Identification of Amphidinols Produced by
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Content, Ratio and Productivity of Amphidinols in Wild-Type and Mutagenized Strains ofMarine drugs · 2026Article
- Article
- Bioactivity of Amphidinol-Containing Extracts of Amphidinium carterae Grown Under Varying Cultivation Conditions.Current microbiology · 2024Article
- Review
- Acute Toxicity of the DinoflagellateToxics · 2023Article
- Article
- Rapid Screening of Polyol Polyketides from Marine Dinoflagellates.Analytical chemistry · 2022Article
- Review
- Antibacterial Activity and Amphidinol Profiling of the Marine DinoflagellateInternational journal of molecular sciences · 2021Article
- Isolation and Structural Elucidation of New Amphidinol Analogues fromMarine drugs · 2021Article
- Toxicity Bioassay and Cytotoxic Effects of the Benthic Marine DinoflagellateJournal of xenobiotics · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphidinols are polyketides produced by dinoflagellates suspected of causing fish kills. Here, we demonstrate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the identification and quantification of amphidinols (AM). Novel AM were detected by neutral loss (NL) scan and then quantified together with known AM by selection reaction monitoring (SRM). With the new method, AM were detected in four of eight analyzed strains with a maximum of 3680 fg toxin content per cell. In total, sixteen novel AM were detected by NL scan and characterized via their fragmentation patterns. Of these, two substances are glycosylated forms. This is the first detection of glycosylated AM.
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