Evidence map›Paper›PMID 33003444›Full record

ArticleCancers2020

The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study.

Eleonora De Martino, Davide Brunetti, Vincenzo Canzonieri, Claudio Conforti, Klaus Eisendle, Guido Mazzoleni, Carla Nobile, Federica Rao, Johannes Zschocke, Emina Jukic and 8 more

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluation of a Set of miRNAs in 26 Cases of Fatal Traumatic Brain Injuries.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eleonora De MartinoDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0003-0733-7231
Davide BrunettiDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Vincenzo CanzonieriDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0001-6010-0976
Claudio ConfortiDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Klaus EisendleAzienda Sanitaria dell'Alto Adige, 39100 Bolzano, Italy.ORCID 0000-0002-8234-9964
Guido MazzoleniAzienda Sanitaria dell'Alto Adige, 39100 Bolzano, Italy.
Carla NobileAzienda Sanitaria dell'Alto Adige, 39100 Bolzano, Italy.
Federica RaoPathology Unit, IRCCS CRO Aviano-National Cancer Institute, 33081 Aviano, Italy.
Johannes ZschockeInstitute for Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Emina JukicInstitute for Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6909-7005
Wolfram JaschkeDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Georg WeinlichDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Bernhard ZelgerDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Matthias SchmuthDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-4064-1334
Giorgio StantaDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Fabrizio ZanconatiDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Iris ZalaudekDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Serena BoninDSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0002-7349-0296

Funding

Interreg ITAT1018
6 · The paper itself

Abstract

Cutaneous melanoma (CM) incidence is rising worldwide and is the primary cause of death from skin disease in the Western world. Personal risk factors linked to environmental ultraviolet radiation (UVR) are well-known etiological factors contributing to its development. Nevertheless, UVR can contribute to the development of CM in different patterns and to varying degrees. The present study aimed at investigating whether altitude of residence can contribute to the development of specific types of CM and/or influence its progression. To this aim, 306 formalin-fixed and paraffin-embedded (FFPE) tissues from primary CM diagnosed in different geographical areas were submitted to B-RAF proto-oncogene serine/threonine kinase (BRAF) and N-RAS proto-oncogene GTPase (NRAS) mutational status detection and mRNA and miRNA profiling by qPCR. Genes were chosen for their functions in specific processes, such as immune response (

Indexed as

altitudecutaneous melanomamiRNAmolecular profiling

Identifiers

PMID33003444
PMCPMC7599639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.