Evidence map›Paper›PMID 33003443›Full record

ReviewJournal of clinical medicine2020

A Deep Brain Stimulation Trial Period for Treating Chronic Pain.

Prasad Shirvalkar, Kristin K Sellers, Ashlyn Schmitgen, Jordan Prosky, Isabella Joseph, Philip A Starr, Edward F Chang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prasad ShirvalkarDepartment of Anesthesiology (Pain Management), University of California San Francisco, San Francisco, CA 94143, USA.
Kristin K SellersDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0517-2296
Ashlyn SchmitgenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Jordan ProskyDepartment of Anesthesiology (Pain Management), University of California San Francisco, San Francisco, CA 94143, USA.
Isabella JosephDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-4003-2528
Philip A StarrDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2733-4003
Edward F ChangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

Funding

Multisite adaptive brain stimulation for multidimensional treatment of refractory chronic painUH3NS115631 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHIRVALKAR, PRASAD · 2019 to 2023
$6.9M
NINDS NIH HHS UH3 NS115631
6 · The paper itself

Abstract

Early studies of deep brain stimulation (DBS) for various neurological disorders involved a temporary trial period where implanted electrodes were externalized, in which the electrical contacts exiting the patient's brain are connected to external stimulation equipment, so that stimulation efficacy could be determined before permanent implant. As the optimal brain target sites for various diseases (i.e., Parkinson's disease, essential tremor) became better established, such trial periods have fallen out of favor. However, deep brain stimulation trial periods are experiencing a modern resurgence for at least two reasons: (1) studies of newer indications such as depression or chronic pain aim to identify new targets and (2) a growing interest in adaptive DBS tools necessitates neurophysiological recordings, which are often done in the peri-surgical period. In this review, we consider the possible approaches, benefits, and risks of such inpatient trial periods with a specific focus on developing new DBS therapies for chronic pain.

Indexed as

chronic paindeep brain stimulationlead externalizationstereoEEGtrial period

Identifiers

PMID33003443
PMCPMC7600449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.