Evidence map›Paper›PMID 33003441›Full record

ArticleCells2020

Dissecting G

Kira Vanessa Blankenbach, Ralf Frederik Claas, Natalie Judith Aster, Anna Katharina Spohner, Sandra Trautmann, Nerea Ferreirós, Justin L Black, John J G Tesmer, Stefan Offermanns, Thomas Wieland and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Kira Vanessa BlankenbachInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Ralf Frederik ClaasInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Natalie Judith AsterInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Anna Katharina SpohnerInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Sandra TrautmannInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Nerea FerreirósInstitut für Klinische Pharmakologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-1215-0164
Justin L BlackDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
John J G TesmerDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University West Lafayette, West Lafayette, IN 47907-2054, USA.
Stefan OffermannsAbteilung für Pharmakologie, Max-Planck-Institut für Herz- und Lungenforschung, 61231 Bad Nauheim, Germany.
Thomas WielandExperimentelle Pharmakologie Mannheim, European Center for Angioscience, Universität Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0001-8262-8261
Dagmar Meyer Zu HeringdorfInstitut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-1246-9677
Goethe University Frankfurt · DEHeidelberg University · DEMax Planck Institute for Heart and Lung Research · DEPurdue University West Lafayette · USUniversity of North Carolina at Chapel Hill · US

Funding

Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1M
GPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA221289NHLBI NIH HHS R01 HL071818
6 · The paper itself

Abstract

Diverse extracellular signals induce plasma membrane translocation of sphingosine kinase-1 (SphK1), thereby enabling inside-out signaling of sphingosine-1-phosphate. We have shown before that G

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsCell MembraneChromatography, High Pressure LiquidFibroblastsGTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansInositol PhosphatesLysophospholipidsMicePhosphotransferases (Alcohol Group Acceptor)Protein BindingReceptor, Bradykinin B2Rho Guanine Nucleotide Exchange FactorsARHGEF25 protein, humanGTP-Binding Protein alpha Subunits, Gq-G11Inositol PhosphatesLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Receptor, Bradykinin B2Rho Guanine Nucleotide Exchange FactorsSphingosinesphingosine 1-phosphateSphingosine KinaseType C PhospholipasesG-protein-coupled receptorsGαq/11sphingosine-1-phosphatesphingosine kinase

Identifiers

PMID33003441
PMCPMC7599897
OpenAlexW3089784499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.